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Usage

Uses

Used in Pharmaceutical Industry:
[(3-chloropropyl)sulfonyl]methylbenzene is used as a building block for the preparation of various pharmaceuticals. Its unique structure and functional groups allow it to be a key component in the development of new drugs, potentially contributing to the treatment of various medical conditions.
Used in Agrochemical Industry:
In the agrochemical industry, [(3-chloropropyl)sulfonyl]methylbenzene is utilized as a reagent in organic synthesis. Its properties make it suitable for the creation of compounds used in the development of pesticides, herbicides, and other agricultural chemicals, aiming to improve crop protection and yield.
Used in Organic Synthesis:
[(3-chloropropyl)sulfonyl]methylbenzene is used as a reagent in organic synthesis due to its versatile reactivity and functional groups. This allows it to be an intermediate in the synthesis of a wide range of organic compounds, which can be applied in various industries, including pharmaceuticals, materials science, and chemical research.

Upstream product

• 100-53-8 phenylmethanethiol 
• 3492-64-6 sodium benzylmercaptide 
• 109-70-6 1.3-chlorobromopropane 
• 14633-35-3 <<(3-chloropropyl)thio>methyl>benzene 
• 154619-07-5 3-phenylmethanesulfonyl-propan-1-ol 

Downstream Products

• 13557-28-3 2-phenyl-2,3,4,5-tetrahydrothiophene-S,S-dioxide 
• 6633-92-7 ((allylsulfonyl)methyl)benzene 
• 91061-28-8 benzyl 2-propenyl sulfone 
• 51417-12-0 ((cyclopropylsulfonyl)methyl)benzene 
• 154619-07-5 3-phenylmethanesulfonyl-propan-1-ol 
• 213600-06-7 4-amino-5-chloro-2-methoxy-N-((1-(3-benzylsulfonylpropyl)piperidin-4-yl)methyl)-benzamide 

Relevant academic research and scientific papers

Synthesis and pharmacological properties of benzamide derivatives as selective serotonin 4 receptor agonists

A series of 4-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamides with a polar substituent group at the 1-position of the piperidine ring was synthesized and evaluated for its effect on gastrointestinal motility. The benzoyl, phenylsulfonyl, and benzylsulfonyl derivatives accelerated gastric emptying and increased the frequency of defecation. One of them, 4-amino-N-[1-[3-(benzylsulfonyl)propyl]piperidin-4-ylmethyl]-5-chloro-2- methoxybenzamide (13a, Y-36912), was a selective 5-HT4 receptor agonist offering potential as a novel prokinetic with reduced side effects derived from 5-HT3- and dopamine D2 receptor-binding affinity. In the oral route of administration, this compound enhanced gastric emptying and defecation in mice, and has a possibility as a prokinetic agent, which is effective on both the upper and the lower gastrointestinal tract.

BENZOIC ACID COMPOUNDS AND MEDICINAL USE THEREOF

The present invention relates to 4-amino-5-chloro-2-methoxy-N-((1-(3-benzylsulfonylpropyl)piperidin-4-yl)methyl)benzamide, a pharmaceutically acceptable salt thereof and an N-oxide compound thereof, a pharmaceutical composition comprising this compound an

BENZOIC ACID COMPOUNDS AND USE THEREOF AS MEDICAMENTS

Benzoic acid compounds of the formula STR1 wherein each symbol is as defined in the specification, optical isomers thereof and pharmaceutically acceptable salts thereof; pharmaceutical composition comprising this compound and pharmaceutically acceptable additive; and serotonin 4 receptor agonists, gastrointestinal prokinetic agents and therapeutic agents for various gastrointestinal diseases, which comprise this compound as active ingredient. The compounds of the present invention have high and selective affinity for serotonin 4 receptor, and show agonistic effects thereon. Accordingly, they are useful medications for the prophylaxis and treatment of various gastrointestinal diseases, central nervous disorders, cardiac function disorders, urinary diseases, and the like, as well as useful anti-nociceptors for analgesic use which increase threshold of pain.