90875-94-8

Basic information

• Product Name: {[(3-chloropropyl)sulfonyl]methyl}benzene
• CAS NO: 90875-94-8
• Molecular Formula: C₁₀H₁₃ClO₂S
• Molecular Weight: 232.727
• Mol File: 90875-94-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 416.5°C at 760 mmHg
• Flash Point: 205.7°C
• Density: 1.24g/cm³
• Vapor Pressure: 9.19E-07mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: {[(3-chloropropyl)sulfonyl]methyl}benzene(CAS DataBase Reference)
• NIST Chemistry Reference: {[(3-chloropropyl)sulfonyl]methyl}benzene(90875-94-8)
• EPA Substance Registry System: {[(3-chloropropyl)sulfonyl]methyl}benzene(90875-94-8)

Safety Data

• Hazardous Substances Data: 90875-94-8(Hazardous Substances Data)

Usage

General Description

The chemical compound {[(3-chloropropyl)sulfonyl]methyl}benzene, also known as (3-chloropropylsulfonyl)methylbenzene, is an organic compound with the formula C10H13ClO2S. It belongs to the class of compounds known as alkyl aryl ethers, which are ethers where the oxygen atom is bonded to an aryl group and an alkyl group. {[(3-chloropropyl)sulfonyl]methyl}benzene contains a benzene ring and a sulfone functional group, with a 3-chloropropyl group and a methyl group attached to the sulfur atom. It is commonly used as a reagent in organic synthesis and as a building block in the preparation of various pharmaceuticals and agrochemicals. It is also known for its potential use as an intermediate in the synthesis of other organic compounds due to its versatile reactivity and functional groups.

Upstream product

• 3492-64-6 sodium benzylmercaptide 
• 109-70-6 1.3-chlorobromopropane 
• 100-53-8 phenylmethanethiol 
• 14633-35-3 <<(3-chloropropyl)thio>methyl>benzene 
• 154619-07-5 3-phenylmethanesulfonyl-propan-1-ol 

Downstream Products

• 13557-28-3 2-phenyl-2,3,4,5-tetrahydrothiophene-S,S-dioxide 
• 6633-92-7 ((allylsulfonyl)methyl)benzene 
• 91061-28-8 benzyl 2-propenyl sulfone 
• 51417-12-0 ((cyclopropylsulfonyl)methyl)benzene 
• 213600-06-7 4-amino-5-chloro-2-methoxy-N-((1-(3-benzylsulfonylpropyl)piperidin-4-yl)methyl)-benzamide 
• 154619-07-5 3-phenylmethanesulfonyl-propan-1-ol 

Relevant articles and documents

Synthesis and pharmacological properties of benzamide derivatives as selective serotonin 4 receptor agonists

A series of 4-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamides with a polar substituent group at the 1-position of the piperidine ring was synthesized and evaluated for its effect on gastrointestinal motility. The benzoyl, phenylsulfonyl, and benzylsulfonyl derivatives accelerated gastric emptying and increased the frequency of defecation. One of them, 4-amino-N-[1-[3-(benzylsulfonyl)propyl]piperidin-4-ylmethyl]-5-chloro-2- methoxybenzamide (13a, Y-36912), was a selective 5-HT4 receptor agonist offering potential as a novel prokinetic with reduced side effects derived from 5-HT3- and dopamine D2 receptor-binding affinity. In the oral route of administration, this compound enhanced gastric emptying and defecation in mice, and has a possibility as a prokinetic agent, which is effective on both the upper and the lower gastrointestinal tract.

BENZOIC ACID COMPOUNDS AND USE THEREOF AS MEDICAMENTS

Benzoic acid compounds of the formula STR1 wherein each symbol is as defined in the specification, optical isomers thereof and pharmaceutically acceptable salts thereof; pharmaceutical composition comprising this compound and pharmaceutically acceptable additive; and serotonin 4 receptor agonists, gastrointestinal prokinetic agents and therapeutic agents for various gastrointestinal diseases, which comprise this compound as active ingredient. The compounds of the present invention have high and selective affinity for serotonin 4 receptor, and show agonistic effects thereon. Accordingly, they are useful medications for the prophylaxis and treatment of various gastrointestinal diseases, central nervous disorders, cardiac function disorders, urinary diseases, and the like, as well as useful anti-nociceptors for analgesic use which increase threshold of pain.