908836-45-3

Upstream product

• 87-42-3 6-chloro-7H-purine 
• 908836-37-3 Acetic acid (2R,3R,4R,5R)-4-acetoxy-3,5-bis-benzyloxymethyl-2-(6-chloro-purin-9-yl)-tetrahydro-furan-3-yl ester 
• 124-41-4 sodium methylate 

Downstream Products

• 908836-40-8 (2R,3R,4R,5R)-3,5-Bis-benzyloxymethyl-2-(6-methylamino-purin-9-yl)-tetrahydro-furan-3,4-diol 
• 908836-41-9 9-((2R,3R,4R,5R)-3,5-Bis-benzyloxymethyl-3,4-dihydroxy-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one 
• 908836-50-0 (2R,3R,4R,5R)-3,5-Bis-benzyloxymethyl-2-[6,6-bis-(2-hydroxy-ethylsulfanyl)-1,6-dihydro-purin-9-yl]-tetrahydro-furan-3,4-diol 
• 908836-39-5 (2R,3R,4R,5R)-2-(6-Amino-purin-9-yl)-3,5-bis-benzyloxymethyl-tetrahydro-furan-3,4-diol 

Relevant academic research and scientific papers

Synthesis of 2-C-hydroxymethylribofuranosylpurines as potent anti-hepatitis C virus (HCV) agents

On the basis of potent anti-HCV activity of 2′-C-methyladenosine, novel 2′-C-hydroxymethyladenosine analogues 2a-c were synthesized from d-ribose in order to lead to favorable interaction with HCV polymerase. Among compounds tested, adenosine derivative 2

Synthesis and anti-HCV activity of 2′-β-hydroxymethylated nucleosides

Synthesis of 2′-β-hydroxymethyl nucleosides 3-6 was accomplished, using stereoselective hydroxymethylation as a key step. Adenine nucleoside 3 showed potent anti-HCV activity, implying that 2′-β- hydroxymethyl group has the appropriate electronic properti