908856-00-8Relevant articles and documents
Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase
Donelson, James L.,Hodges, Heather B.,MacDougall, Daniel D.,Henriksen, Brian S.,Hrycyna, Christine A.,Gibbs, Richard A.
, p. 4420 - 4423 (2007/10/03)
N-Acetyl-S-farnesyl-l-cysteine (AFC) is the minimal substrate for the enzyme isoprenylcysteine carboxyl methyltransferase (Icmt). A series of amide-modified farnesylcysteine analogs were synthesized and screened against human Icmt. From a 23-membered libr