91-84-9 Usage
Uses
Used in Pharmaceutical Industry:
PYRILAMINE is used as an antihistaminic agent for the treatment of allergy symptoms and rhinitis. It works by blocking the action of histamine, a chemical released during an allergic reaction, thereby providing relief from allergy symptoms.
Used in Pain Management:
PYRILAMINE is used in synergism with diclofenac as a therapeutic alternative for the clinical management of inflammatory pain. The combination of PYRILAMINE and diclofenac helps in reducing inflammation and pain associated with various conditions.
Synthesis Reference(s)
Journal of the American Chemical Society, 68, p. 1999, 1946 DOI: 10.1021/ja01214a037
Air & Water Reactions
May be sensitive to light. Insoluble in water.
Reactivity Profile
PYRILAMINE neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate flammable gaseous hydrogen in combination with strong reducing agents, such as hydrides.
Health Hazard
SYMPTOMS: Exposure to PYRILAMINE may cause somnolence, central nervous system depression and gastrointestinal disturbances. It may also cause drowsiness, dryness of the mouth, headache, nausea, tachycardia, urinary retention, nervousness, disorientation, staggering gait, hallucinations, stupor, coma, hyperflexia, tremors, excitement, nystagmus, hyperthermia, convulsions, agranulocytosis and aplastic anemia.
Fire Hazard
Flash point data for PYRILAMINE are not available; however, PYRILAMINE is probably combustible.
Check Digit Verification of cas no
The CAS Registry Mumber 91-84-9 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 1 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 91-84:
(4*9)+(3*1)+(2*8)+(1*4)=59
59 % 10 = 9
So 91-84-9 is a valid CAS Registry Number.
InChI:InChI=1/C17H23N3O/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15/h4-11H,12-14H2,1-3H3
91-84-9Relevant academic research and scientific papers
Photoredox-catalyzed decarboxylative cross-coupling of α-amino acids with nitrones
Li, Heng-Hui,Li, Jia-Qi,Zheng, Xiao,Huang, Pei-Qiang
, p. 876 - 880 (2021/02/01)
A decarboxylative cross-coupling reaction of α-amino acids with nitrones via visible-light-induced photoredox catalysis has been established for easy access to β-amino hydroxylamines and vicinal diamines with structural diversity, which is featured with simple operation, mild conditions, readily available α-amino acids, and a broad scope of nitrone substrates. The application of this protocol can furnish efficient synthetic strategies for some valuable vicinal diamine-containing molecules.
Reinvestigating Raney nickel mediated selective alkylation of amines with alcohols via hydrogen autotransfer methodology
Mehta, Astha,Thaker,Londhe,Nandan, Santosh R.
, p. 241 - 251 (2014/05/20)
An efficient, cost-effective use of Raney nickel (R-Ni) a widely used industrial catalyst for N-alkylation using alcohols is highlighted here. The work describes the scope and capability of R-Ni in hydrogen autotransfer reactions enabling its widespread use in the Chemical and Pharmaceutical industry. R-Ni of W4, T4, and W7 grades were prepared and evaluated for alkylation of amines. The best activity and selectivity for mono alkylation of amines were obtained using W4 R-Ni at 1:4 moles of amine to alcohol in xylene at reflux. T4 R-Ni also showed ability to form stable imines. The prepared R-Ni was also recycled and reused for N-alkylation reaction. The optimized methodology was applied for synthesis of Active Pharmaceutical ingredients Piribedil and Mepyramine. The simplicity and wide substrate scope makes this method a preferred Hydrogen Auto-transfer protocol for the alkylation of amines.
