91000-11-2

Usage

Uses

Used in Pharmaceutical Industry:
(2E)-N-(4-aminobutyl)-3-(4-hydroxy-3-methoxyphenyl)propenamide is used as a potential therapeutic agent for the treatment of inflammatory and autoimmune disorders. Its antioxidant and anti-inflammatory properties make it a promising candidate for the development of new pharmacological agents.
Used in Cancer Therapy:
(2E)-N-(4-aminobutyl)-3-(4-hydroxy-3-methoxyphenyl)propenamide is used as a potential agent in cancer therapy. Further research and clinical studies are needed to fully understand its medicinal properties and potential applications in this field.

Upstream product

• 1135-24-6 (E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid 
• 110-60-1 1,4-diaminobutane 
• 89091-72-5 Methanesulfonic acid 4-[(E)-2-(4-bromo-butylcarbamoyl)-vinyl]-2-methoxy-phenyl ester 
• 89091-70-3 Methanesulfonic acid 4-((E)-2-chlorocarbonyl-vinyl)-2-methoxy-phenyl ester 
• 50906-12-2 4-acetoxy-3-methoxycinnamoyl chloride 

Relevant academic research and scientific papers

Merging memantine and ferulic acid to probe connections between NMDA receptors, oxidative stress and amyloid-β peptide in Alzheimer's disease

N-methyl-D-aspartate receptors (NMDAR) are critically involved in the pathogenesis of Alzheimer's disease (AD). Acting as an open-channel blocker, the anti-AD drug memantine preferentially targets NMDAR overactivation, which has been proposed to trigger neurotoxic events mediated by amyloid β peptide (Aβ) and oxidative stress. In this study, we applied a multifunctional approach by conjugating memantine to ferulic acid, which is known to protect the brain from Aβ neurotoxicity and neuronal death caused by ROS. The most interesting compound (7) behaved, like memantine, as a voltage-dependent antagonist of NMDAR (IC50 = 6.9 μM). In addition, at 10 μM concentration, 7 exerted antioxidant properties both directly and indirectly through the activation of the Nrf-2 pathway in SH-SY5Y cells. At the same concentration, differently from the parent compounds memantine and ferulic acid alone, it was able to modulate Aβ production, as revealed by the observed increase of the non-amyloidogenic sAPPα in H4-SW cells. These findings suggest that compound 7 may represent a promising tool for investigating NMDAR-mediated neurotoxic events involving Aβ burden and oxidative damage.

Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus

A library of hydroxycinnamic acid amides (HCAAs) and analogues were synthesized using solid-phase synthesis technique. These compounds were screened for antibacterial against methicillin-resistant Staphylococcus aureus (MRSA) (11 strains) and vancomycin-r

N-Feruloylputrescine in Infected Potato Tubers

N-Feruloylputrescine has been isolated from the blue fluorescent stress zone of potato tubers (cv.Bintje) infected by Phoma exigua var. foveata.Analysis of various parts of the infected tubers for this compound was performed by HPLC and TLC.

AN EFFICIENT SYNTHESIS OF SOME BIOLOGICALLY IMPORTANT MONOACYLATED DIAMINES

Some biologically important monoacylated diamines were synthesyzed via azide intermediates in good yield.