91000-13-4

Usage

Uses

Used in Pharmaceutical Industry:
(2E,2'E)-N,N'-(butane-1,4-diyl)bis(3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide) is used as a pharmaceutical agent for its potential antioxidative and anti-inflammatory properties. The presence of hydroxy and methoxy groups in the phenyl rings may contribute to its ability to combat oxidative stress and reduce inflammation, making it a promising candidate for the development of new drugs targeting various diseases and conditions.
Used in Cosmetics Industry:
In the cosmetics industry, (2E,2'E)-N,N'-(butane-1,4-diyl)bis(3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide) is used as an active ingredient for its potential skin health benefits. Its antioxidative properties may help protect the skin from environmental damage, while its anti-inflammatory effects could soothe and calm irritated skin, making it suitable for inclusion in skincare products.
Used in Chemical Synthesis:
(2E,2'E)-N,N'-(butane-1,4-diyl)bis(3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide) is used as a structural intermediate in the synthesis of other organic compounds. Its unique chemical structure allows it to serve as a building block or precursor in the creation of more complex molecules, which could have various applications in different industries, including pharmaceuticals, materials science, and specialty chemicals.
Further research and development are necessary to fully understand the potential uses and effects of (2E,2'E)-N,N'-(butane-1,4-diyl)bis(3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide) in these and other industries.

Upstream product

• 50906-12-2 4-acetoxy-3-methoxycinnamoyl chloride 
• 110-60-1 1,4-diaminobutane 
• 86530-09-8 (E)-3-(4-Hydroxy-3-methoxy-phenyl)-acrylic acid piperidin-1-yl ester 
• 1135-24-6 (E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid 
• 86530-08-7 (E)-3-(3-Methoxy-4-methoxycarbonyloxy-phenyl)-acrylic acid piperidin-1-yl ester 

Downstream Products

• 1354794-10-7 N,N'-(butane-1,4-diyl)bis(3-(4-hydroxy-3-methoxyphenyl)propanamide) 

Relevant academic research and scientific papers

Ferulic acid amide derivatives as anticancer and antioxidant agents: synthesis, thermal, biological and computational studies

Abstract: The design and microwave-assisted synthesis of four series (IIIa–IIIo, Va–Vg, VIIa–VIIg and IXa–IXe) of mono and bis-amide derivatives of ferulic acid have been achieved under solvent-free conditions and, subsequently characterized by spectroscopic techniques. During thermal analysis, all the compounds were found stable up to 100?°C and decomposed through single step at higher temperature. The derivatives were screened for their in vitro cytotoxicity and antioxidant activity, respectively and observed that compound Vb was most active against breast (MCF-7; IC50?=?07.49?μM and MDA-MB-231; IC50?=?07.28?μM), Vd against lung (A549; IC50?=?07.11?μM) and liver (HepG2; IC50?=?08.32?μM), and Ve against cervical (HeLa; IC50?=?07.14?μM) cancer cell lines, while compounds IIIf, IIIl, IIIo, VIIe and IXa–IXe were found to exhibit the strong antioxidant activity with respect to their parent molecule. Previous reports for the biological applications of ferulic acid amides also confirmed the importance of work presented here. The 3D-QSAR studies for anticancer and antioxidant activities were also performed by using CoMFA, and the corresponding contour maps of electrostatic and steric fields have been computed. Statistical analysis between experimental and CoMFA-predicted data for pIC50 have been accomplished by curve fitting analysis which showed the significant correlation. Graphical Abstract: [Figure not available: see fulltext.]

Synthesis of Actinomycetes natural products JBIR-94, JBIR-125, and related analogues

The synthesis of the natural products JBIR-94, DCP, DFP, and CFP is reported. A strategy for the coupling of ferulic or coumaric acid to putrescine is described. We determined that EDCI was the most effective coupling agent for this synthesis. In addition amide coupling with saturated cinnamic acids derivatives provided the best yield. The synthesis of JBIR-125 is accomplished through a novel synthesis of differentially protected spermidine. Preliminary bioassay data demonstrated that all five compounds were active against Pseudomonas aeruginosa.

N-Feruloylputrescine in Infected Potato Tubers

N-Feruloylputrescine has been isolated from the blue fluorescent stress zone of potato tubers (cv.Bintje) infected by Phoma exigua var. foveata.Analysis of various parts of the infected tubers for this compound was performed by HPLC and TLC.

A SHORT AND EFFICIENT SYNTHESIS OF PHENOLCARBOXAMIDES

The selective acylation of primary amine functions of polyamines with acylating agents derived from unprotected mono or o-dihydroxy aromatic acids is described.The key step of the method is the transient protection of the phenol groups during the preparation of the hydroxy-1-piperidine active esters.This method is especially applicable to the preparation of the radiolabelled polyamine derivatives.