91004-38-5

Basic information

• Product Name: 3-(Acetylamino)-4-hydroxybenzoic acid
• Synonyms: 3-(Acetylamino)-4-hydroxybenzoic acid;3-Acetamido-4-hydroxybenzoicacid
• CAS NO: 91004-38-5
• Molecular Formula: C₉H₉NO₄
• Molecular Weight: 195.17206
• Mol File: 91004-38-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(Acetylamino)-4-hydroxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Acetylamino)-4-hydroxybenzoic acid(91004-38-5)
• EPA Substance Registry System: 3-(Acetylamino)-4-hydroxybenzoic acid(91004-38-5)

Safety Data

• Hazardous Substances Data: 91004-38-5(Hazardous Substances Data)

Upstream product

• 536-25-4 methyl 3-amino-4-hydroxybenzoate 
• 1571-72-8 3-amino-4-hydroxybenzoic acid 
• 126360-59-6 methyl 3-(N-acetyl)amino-4-hydroxybenzoate 
• 108-24-7 acetic anhydride 

Downstream Products

• 126360-59-6 methyl 3-(N-acetyl)amino-4-hydroxybenzoate 
• 848133-76-6 7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile 
• 848133-75-5 3-cyano-4-hydroxyl-6-acetamido-7-ethoxyquinoline 
• 1222172-51-1 ethyl 5-acetamido-2-amino-4-ethoxybenzoate 
• 780821-04-7 ethyl 3-acetamido-4-ethoxybenzoate 
• 1356916-92-1 3-acetamido-4-ethoxybenzoic acid 
• 1436405-84-3 2-amino-N-(3-chloro-4-fluorophenyl)-4-ethoxy-5-(4-((4-methylpiperazin-1-yl)methyl)benzamido)benzamide 
• 1436405-83-2 N-(3-chloro-4-fluorophenyl)-4-ethoxy-5-(4-((4-methylpiperazin-1-yl)methyl)benzamido)-2-nitrobenzamide 
• 1436405-82-1 2-amino-N-(3-chloro-4-fluorophenyl)-5-(4-(dimethylamino)but-2-enamido)-4-ethoxybenzamide 
• 1436405-81-0 N-(3-chloro-4-fluorophenyl)-5-(4-(dimethylamino)but-2-enamido)-4-ethoxy-2-nitrobenzamide 
• 1436405-80-9 5-amino-N-(3-chloro-4-fluorophenyl)-4-ethoxy-2-nitrobenzamide 
• 1436405-79-6 2-amino-N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-4-ethoxy-5-(4-((4-methylpiperazin-1-yl)methyl)benzamido)benzamide 
• 1436405-78-5 N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-4-ethoxy-5-(4-((4-methylpiperazin-1-yl)methyl)benzamido)-2-nitrobenzamide 
• 1436405-77-4 2-amino-N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-5-(4-(dimethylamino)but-2-enamido)-4-ethoxybenzamide 

Relevant articles and documents

Identification of ortho-hydroxy anilide as a novel scaffold for lysine demethylase 5 inhibitors

Fe(II)/α-ketoglutarate-dependent lysine demethylases (KDMs) are attractive drug targets for several diseases including cancer. In this study, we designed and screened ortho-substituted anilides that are expected to function as Fe(II) chelators, and identified ortho-hydroxy anilide as a novel scaffold for KDM5A inhibitors. Treatment of human lung cancer A549 cells with a prodrug form of 4-carboxy-2-hydroxy-formanilide (9c) increased trimethylated lysine 4 on histone H3 level, suggesting KDM5 inhibition in the cells.

Preparation method of Neratinib intermediate

The invention relates to the field of chemical synthesis, and specifically relates to a preparation method of a Neratinib intermediate. A compound (I) is taken as the raw material, and through a series of reactions, the intermediate compound (VIII) of a novel antitumor drug Neratinib is obtained. A high efficient synthesis route is provided and has the characteristics of low cost, few byproducts, high yield, and little environmental pollution.