1356916-92-1

Basic information

• Product Name: 3-acetamido-4-ethoxybenzoic acid
• Synonyms: 3-acetamido-4-ethoxybenzoic acid
• CAS NO: 1356916-92-1
• Molecular Weight: 223.229
• Mol File: 1356916-92-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-acetamido-4-ethoxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-acetamido-4-ethoxybenzoic acid(1356916-92-1)
• EPA Substance Registry System: 3-acetamido-4-ethoxybenzoic acid(1356916-92-1)

Safety Data

• Hazardous Substances Data: 1356916-92-1(Hazardous Substances Data)

Upstream product

• 74-96-4 ethyl bromide 
• 91004-38-5 3-acetamido-4-hydroxybenzoic acid 
• 536-25-4 methyl 3-amino-4-hydroxybenzoate 
• 126360-59-6 methyl 3-(N-acetyl)amino-4-hydroxybenzoate 
• 1201080-20-7 methyl 3-acetamido-4-ethoxybenzoate 

Downstream Products

• 1201080-09-2 N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide 
• 1201080-46-7 5-acetamido-4-ethoxy-2-nitrobenzoyl chloride 
• 1201080-29-6 5-acetamido-4-ethoxy-2-nitrobenzoic acid 
• 1201079-42-6 ethyl 3-(5-acetamido-4-ethoxy-2-nitrophenyl)-2-cyano-3-oxopropanoate 
• 1201079-16-4 N-[5-(2-cyanoacetyl)-2-ethoxy-4-nitrophenyl]acetamide 
• 1201079-19-7 N-{5-[2-cyano-3-(N,N-dimethylamino)acryloyl]-2-ethoxy-4-nitrophenyl}acetamide 
• 1436405-70-7 5-amino-N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-4-ethoxy-2-nitrobenzamide 
• 1436405-71-8 N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-5-(4-(dimethylamino)but-2-enamido)-4-ethoxy-2-nitrobenzamide 
• 1436405-72-9 2-amino-N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-5-(4-(dimethylamino)but-2-enamido)-4-ethoxybenzamide 
• 1436405-73-0 N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-4-ethoxy-5-(4-((4-methylpiperazin-1-yl)methyl)benzamido)-2-nitrobenzamide 
• 1436405-74-1 2-amino-N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-4-ethoxy-5-(4-((4-methylpiperazin-1-yl)methyl)benzamido)benzamide 
• 1436405-75-2 5-amino-N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-4-ethoxy-2-nitrobenzamide 
• 1436405-76-3 N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-5-(4-(dimethylamino)but-2-enamido)-4-ethoxy-2-nitrobenzamide 
• 1436405-77-4 2-amino-N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-5-(4-(dimethylamino)but-2-enamido)-4-ethoxybenzamide 

Relevant articles and documents

Preparation method of Neratinib intermediate

The invention relates to the field of chemical synthesis, and specifically relates to a preparation method of a Neratinib intermediate. A compound (I) is taken as the raw material, and through a series of reactions, the intermediate compound (VIII) of a novel antitumor drug Neratinib is obtained. A high efficient synthesis route is provided and has the characteristics of low cost, few byproducts, high yield, and little environmental pollution.

Synthesis of n-(3-cyano-7-ethoxy-1,4-dihydro-4-oxoquinolin-6-yl)acetamide

New route for the preparation of N-(3-cyano-7-ethoxy-1,4-dihydro-4- oxoquinolin-6-yl)acetamide (1), a key intermediate for the synthesis of selective EGFR kinase inhibitors, was described.