910131-68-9Relevant academic research and scientific papers
Total synthesis of the β-methoxyacrylate-based fungicide myxothiazol
Martin, Bruce J.,Clough, John M.,Pattenden, Gerald,Waldron, Ian R.
, p. 5151 - 5154 (1993)
A total synthesis of the novel antifungal substance myxothiazol 1 isolated from the myxobacterium Myxococcus fulvus is described. The synthesis is based on elaboration of the S-E,E-diene thioamide 1 5 and the 2R S, 3S R amide aldehyde 2 5 as key intermedi
Total synthesis of myxothiazols, novel bis-thiazole β-methoxyacrylate- based anti-fungal compounds from myxobacteria
Clough, John M.,Dube, Henry,Martin, Bruce J.,Pattenden, Gerald,Reddy, K. Srinivasa,Waldron, Ian R.
, p. 2906 - 2911 (2008/02/09)
Convergent total syntheses of myxothiazols A and Z are described. The syntheses are based on elaboration of the (S)-E,E-diene thioamide 22, conversion of 22 into the bis-thiazole 27 and Wittig reactions between 27c and the aldehyde 30. The substituted β-m
