910136-50-4Relevant academic research and scientific papers
Electronic control of product distribution in the [5+5]-coupling of ortho-alkynylbenzaldehyde derivatives and γ,δ-unsaturated carbene complexes
Camacho-Davila, Alejandro,Gamage, Lalith S.R.,Wang, Zhipeng,Herndon, James W.
supporting information; experimental part, p. 4954 - 4960 (2010/08/19)
The coupling of highly oxygenated ortho-alkynylbenzaldehyde derivatives with γ,δ-carbene complexes was evaluated systematically. In all of the electron-rich systems investigated the exclusive product of the reaction is the dihydrophenanthrene derivative.
Cascade reactions: Catalytic synthesis of functionalized 1,3-dihydroisobenzofuran and tetrahydrofuran derivatives by sequential nucleophilic ring opening-heterocyclization-oxidative carbonylation of alkynyloxiranes
Della Ca, Nicola,Campanini, Fabio,Gabriele, Bartolo,Salerno, Giuseppe,Massera, Chiara,Costa, Mirco
supporting information; scheme or table, p. 2423 - 2432 (2009/12/28)
Differently substituted alkynyloxiranes were efficiently converted into functionalized 1,3-dihydroisobenzofurans and tetrahydrofuran derivatives in fair to good yields by a new cascade reaction, consisting of a sequential nucleophilic ring opening-heteroc
Total synthesis of antofine using the net [5+5]-cycloaddition of γ,δ-unsaturated carbene complexes and 2-alkynylphenyl ketones as a key step
Camacho-Davila, Alejandro,Herndon, James W.
, p. 6682 - 6685 (2007/10/03)
A compound containing all of the carbons of the anticancer agent antofine was produced in a single step from the coupling of a γ,δ-unsaturated carbene complex with a 2-alkynylphenyl ketone derivative. Subsequent conversion to antofine was effected in three steps.
