910136-53-7

Upstream product

• 910136-50-4 4,5-dimethoxy-2-(2-trimethylsilylethynyl)acetophenone 
• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 106824-48-0 4,5-dimethoxy-2-((trimethylsilyl)ethynyl)benzaldehyde 

Downstream Products

• 910136-49-1 2-[2-(4,5-dimethoxy-2-trimethylsilanylethynyl-phenyl)-2-oxo-ethyl]-pyrrolidine-1-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Total synthesis of antofine using the net [5+5]-cycloaddition of γ,δ-unsaturated carbene complexes and 2-alkynylphenyl ketones as a key step

A compound containing all of the carbons of the anticancer agent antofine was produced in a single step from the coupling of a γ,δ-unsaturated carbene complex with a 2-alkynylphenyl ketone derivative. Subsequent conversion to antofine was effected in three steps.