91016-81-8Relevant academic research and scientific papers
Visible-Light-Driven, Copper-Catalyzed Decarboxylative C(sp3)?H Alkylation of Glycine and Peptides
Wang, Chao,Guo, Mengzhun,Qi, Rupeng,Shang, Qinyu,Liu, Qiang,Wang, Shan,Zhao, Long,Wang, Rui,Xu, Zhaoqing
, p. 15841 - 15846 (2018)
Despite a well-developed and growing body of work in Cu catalysis, the potential of Cu to serve as a photocatalyst remains underexplored. Reported herein is the first example of visible-light-induced Cu-catalyzed decarboxylative C(sp3)?H alkylation of glycine for preparing α-alkylated unnatural α-amino acids. It merits mentioning that the mild conditions and the good functional-group tolerance allow the modification of peptides using this method. The mechanistic studies revealed that a radical–radical coupling pathway is involved in the reaction.
Visible-Light-Promoted C(sp3)?H Alkylation by Intermolecular Charge Transfer: Preparation of Unnatural α-Amino Acids and Late-Stage Modification of Peptides
Wang, Chao,Qi, Rupeng,Xue, Hongxiang,Shen, Yuxuan,Chang, Min,Chen, Yaqiong,Wang, Rui,Xu, Zhaoqing
, p. 7461 - 7466 (2020)
Disclosed herein is the visible-light-promoted deaminative C(sp3)?H alkylation of glycine and peptides using Katritzky salts as electrophiles. Simple reaction conditions and excellent functional-group tolerance provide a general strategy for th
Visible-light promoted α-alkylation of glycine derivatives with alkyl boronic acids
Wang, Jiayuan,Su, Yingpeng,Quan, Zhengjun,Li, Jun,Yang, Jie,Yuan, Yong,Huo, Congde
, p. 1959 - 1962 (2021)
A visible-light-mediated aerobic α-alkylation reaction of glycine derivatives with alkyl boronic acids has been established in the presence of a Ru/Cu catalyst system, giving the desired radical coupling products efficiently. The transformation features m
