910296-60-5Relevant academic research and scientific papers
Synthesis of a novel plant growth promoter from gallic acid
Negi, Arvind Singh,Darokar, Mahinder P.,Chattopadhyay, Sunil K.,Garg, Ankur,Bhattacharya, Asish K.,Srivastava, Vandana,Khanuja, Suman P. S.
, p. 1243 - 1247 (2005)
Gallic acid has been modified to naphthophenone derivatives with esterified fatty acid side chain. Compound 12, an ethyl crotonate ester of naphthophenone derivative has shown potent auxin like growth promoter activity. This is the first example of naphthophenone derivatives with plant growth promoting activity.
Synthesis of gallic acid based naphthophenone fatty acid amides as cathepsin D inhibitors
Srivastava, Vandana,Saxena, Hari Om,Shanker, Karuna,Kumar,Luqman, Suaib,Gupta,Khanuja,Negi, Arvind S.
, p. 4603 - 4608 (2007/10/03)
Gallic acid, one of the most abundant plant phenolic acids, has been modified to cathepsin D protease inhibitors. The strategy of modification was proposed basing on some previously reported structure and activity relationship (SAR) studies. The synthesized naphthophenone fatty acid amide derivatives have been evaluated for in vitro cathepsin D inhibition activity. Two of them have shown significant inhibition activity with IC50 values of 0.06 and 0.14 μM, respectively, as compared against pepstatin (0.0023 μM), the most potent inhibitor known so far. The study revealed that such attempts on gallic acid based pharmacophores might result in potent inhibitors of cathepsin D.
