910315-64-9Relevant academic research and scientific papers
Pyrazolo[1′,5′:1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A1 adenosine receptor ligands
Giovannoni, Maria Paola,Vergelli, Claudia,Cilibrizzi, Agostino,Crocetti, Letizia,Biancalani, Claudio,Graziano, Alessia,Piaz, Vittorio Dal,Loza, Maria Isabel,Cadavid, Maria Isabel,Díaz, José Luis,Gavald, Amadeu
scheme or table, p. 7890 - 7899 (2011/01/13)
A series of pyrazolo[1′,5′:1,6]pyrimido[4,5-d]pyridazin-4(3H)- ones was synthesized and tested in radioligand binding assays to determine their affinities for the human adenosine A1, A2A, A 2B and A3 receptors.
Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase 5 (PDE5) inhibitory activity as potential agents for treatment of erectile dysfunction
Giovannoni, Maria Paola,Vergelli, Claudia,Biancalani, Claudio,Cesari, Nicoletta,Graziano, Alessia,Biagini, Pierfrancesco,Gracia, Jordi,Gavaldà, Amadeu,Dal Piaz, Vittorio
, p. 5363 - 5371 (2007/10/03)
Pyrazolo[1′,5′:1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones and their analogues, potentially useful for the treatment of erectile dysfunction, were synthesized and evaluated as inhibitors of phosphodiesterase 5 (PDE5). Several compounds showed IC50
