910315-83-2

Upstream product

• 15911-16-7 3,4-dimethyl-6H-isoxazolo[3,4-d]pyridazin-7-one 
• 910315-64-9 6-benzyl-3,4-dimethylisoxazolo[3,4-d]pyridazin-7(6H)-one 
• 3446-89-7 4-(Methylthio)benzaldehyde 

Downstream Products

• 910315-97-8 4-amino-2-benzyl-6-methyl-5-[5-(4-methylsulfanyl-phenyl)-2H-pyrazol-3-yl]-2H-pyridazin-3-one 

Relevant academic research and scientific papers

Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase 5 (PDE5) inhibitory activity as potential agents for treatment of erectile dysfunction

Pyrazolo[1′,5′:1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones and their analogues, potentially useful for the treatment of erectile dysfunction, were synthesized and evaluated as inhibitors of phosphodiesterase 5 (PDE5). Several compounds showed IC50