910546-48-4

Basic information

• Product Name: (1-(4-methoxyphenyl)-1H-(1,2,3)triazol-4-yl)methanol
• Synonyms: (1-(4-methoxyphenyl)-1H-(1,2,3)triazol-4-yl)methanol
• CAS NO: 910546-48-4
• Molecular Weight: 205.216
• Mol File: 910546-48-4.mol
• Article Data: 31

Chemical Properties

• CAS DataBase Reference: (1-(4-methoxyphenyl)-1H-(1,2,3)triazol-4-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1-(4-methoxyphenyl)-1H-(1,2,3)triazol-4-yl)methanol(910546-48-4)
• EPA Substance Registry System: (1-(4-methoxyphenyl)-1H-(1,2,3)triazol-4-yl)methanol(910546-48-4)

Safety Data

• Hazardous Substances Data: 910546-48-4(Hazardous Substances Data)

Upstream product

• 2101-87-3 p-methoxy-phenylazide 
• 104-94-9 4-methoxy-aniline 
• 107-19-7 propargyl alcohol 
• 5720-07-0 4-methoxyphenylboronic acid 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 1325725-21-0 1-(4-methoxyphenyl)-4-vinyl-1H-1,2,3-triazole 
• 133902-64-4 1-(4-methoxyphenyl)-4,5-dihydro-1H-1,2,3-triazole-4-carbaldehyde 
• 1613039-75-0 N-((1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)methylene)-1-phenylmethanamine oxide 
• 1613039-83-0 N-((1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)methylene)-2-methylpropan-2-amine oxide 
• 1096131-08-6 4-(bromomethyl)-1-(4-methoxyphenyl)-1H-1,2,3-triazole 
• 4916-13-6 1-(4-methoxyphenyl)-1H-[1,2,3]-triazolyl-4-carboxylic acid 
• 68535-49-9 1-(4-methoxyphenyl)-1H-[1,2,3]triazole 

Relevant articles and documents

[HDBU][HSO4]-catalyzed facile synthesis of new 1,2,3-triazole-tethered 2,3-dihydroquinazolin-4[1H]-one derivatives and their DPPH radical scavenging activity

A simple and efficient protocol has been developed for the synthesis of new1,2,3-triazole-2,3-dihydroquinazolin-4[1H]-one (DHQ) conjugates(6a?j) via ultrasound-assisted, solvent-free ionic liquid [HDBU][HSO4]-catalyzed reaction in good to excellent yields. This non-conventional, ultrasound-assisted route has taken the reactions over the conventional reflux method to provide good to excellent yields of the corresponding products (6a?j) in a very short time. In addition, mild reaction conditions, tolerance to functionalized substrates, ease of product isolation, prevention of its over oxidation and reusability of catalyst [HDBU][HSO4] are some key striking features of the methodology. The newly synthesized derivatives (6a?j) were screened for antioxidant activity using 1,1-diphenyl-2-picryl hydrazyl (DPPH) assay and are found to be a potent scavenger. The compounds 6b, 6c, 6d, 6e and 6i showed significant antioxidant activity. Molecular docking studies showed significant binding affinity in the active site of myeloperoxidase (MPO) enzyme and hence scavenged by inhibition of MPO. In silico ADMET and pharmacokinetic studies of the conjugates are very promising; a cumulative body of evidence suggests their medicinal value as a potential orally active drug candidate. Graphical abstract: [Figure not available: see fulltext.]

Synthesis, antiproliferative and antitrypanosomal activities, and DNA binding of novel 6-amidino-2-arylbenzothiazoles

A series of 6-amidinobenzothiazoles, linked via phenoxymethylene or directly to the 1,2,3-triazole ring with a p-substituted phenyl or benzyl moiety, were synthesised and evaluated in?vitro against four human tumour cell lines and the protozoan parasite T

Synthesis and Anticancer Activity of (E)-5-[(1-Aryl-1H-1,2,3-triazol-4-yl)methylene]thiazolidine-2,4-diones

Abstract: A novel series of 1,2,3-triazolylthiazolidinedione analogs have been synthesized by the condensation of the corresponding 1-aryl-1H-1,2,3-triazole-4-carbaldehydes with thiazolidine-2,4-dione in the presence of KOH. The title compounds were evaluated for their in vitro anticancer activity using MTT assay against four cancer cell lines: A549 (lung), HT-29 (colon), MCF-7 (breast), and A375 (melanoma). Most compounds displayed good anticancer activity, but hydroxy- and nitro-substituted derivatives showed higher activity than the others.