91058-98-9Relevant academic research and scientific papers
HCK INHIBITORS FOR THE TREATMENT OF FIBROSIS AND CANCER
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Paragraph 00109, (2020/10/20)
Compounds which are thiazole and triazole derivatives are disclosed, including compounds of the following genus: Formula I. The compounds are inhibitors of hematopoietic cell kinase (HCK) and exhibit anti-fibrotic and anti-proliferative effects. They are useful in the treatment of a variety of disorders, including a fibrosis or a fibrotic disease, such as renal fibrosis.
A sustainable innovation for the tandem synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL im from: Thermomyces lanuginosus in continuous-flow microreactors
Chen, Ping-Feng,Du, Li-Hua,Long, Rui-Jie,Luo, Xi-Ping,Xue, Miao
, p. 13252 - 13259 (2020/04/22)
We developed an efficient and environmentally friendly two-step tandem methodology for the synthesis of sugar-containing coumarin derivatives catalyzed by lipozyme TL IM from Thermomyces lanuginosus in continuous-flow microreactors. Compared to those observed for other methods, the salient features of this work including green reaction conditions, short residence time (50 min), and catalysts are more readily available and the biocatalysis reaction process is efficient and easy to control. This two-step tandem synthesis of coumarin derivatives using the continuous-flow technology is a proof of concept that opens the use of enzymatic microreactors in coumarin derivative biotransformations.
Coumarin-3-carboxylic acid ester derivative preparation method
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Paragraph 0045; 0050-0054, (2017/02/02)
The invention discloses a preparation method for a coumarin-3-carboxylic ester derivative shown as the formula (I) or the formula (II) in the specification. The method comprises the step that under the existence of FeCl3 being used as a catalyst, salicylaldehyde derivative shown as the formula (III) in the specification and 2-hydroxy-1-naphthaldehyde shown as the formula (IV) in the specification are in contact reaction with alcohol and meldrum's acid which have a general formula, namely R2OH. Through the fact that the salicylaldehyde derivative, the 2-hydroxy-1-naphthaldehyde, the alcohol or the meldrum's acid is catalyzed by FeCl3 in multi-component contact reaction under a relatively temperate condition, the coumarin-3-carboxylic ester derivative with relatively high productivity is synthesized in relatively short reaction time, and the method is simple in step, efficient and environment-friendly, and completely meets the concept of green chemistry.
Synthesis of coumarin-3-carboxylic esters via FeCl3-catalyzed multicomponent reaction of salicylaldehydes, Meldrum's acid and alcohols
He, Xinwei,Shang, Yongjia,Zhou, Yao,Yu, Zhiyu,Han, Guang,Jin, Wenjing,Chen, Jiaojiao
, p. 863 - 868 (2015/01/30)
A FeCl3-catalyzed multicomponent reaction was developed for the facile synthesis of coumarin-3-carboxylic ester derivatives in a highly atom-economic and environmentally friendly way. Using simple and cheaply available salicylaldehydes, Meldrum's acid and alcohols as the starting materials, the method needs no extra additives and features wide substrate scope, good functional group tolerance and mild reaction conditions.
