91058-98-9

Basic information

• Product Name: Methyl 6-chloro-2-oxo-2H-chromene-3-carboxylate ,97%
• Synonyms: Methyl 6-chloro-2-oxo-2H-chromene-3-carboxylate ,97%;methyl 6-chloro-2-oxo-2H-chromene-3-carboxylate;6-Chloro-2-oxo-2H-1-benzopyran-3-carboxylic acid methyl ester
• CAS NO: 91058-98-9
• Molecular Formula: C11H7ClO4
• Molecular Weight: 238.62388
• Mol File: 91058-98-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 406.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.449±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Methyl 6-chloro-2-oxo-2H-chromene-3-carboxylate ,97%(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 6-chloro-2-oxo-2H-chromene-3-carboxylate ,97%(91058-98-9)
• EPA Substance Registry System: Methyl 6-chloro-2-oxo-2H-chromene-3-carboxylate ,97%(91058-98-9)

Safety Data

• Hazardous Substances Data: 91058-98-9(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Upstream product

• 67-56-1 methanol 
• 2033-24-1 cycl-isopropylidene malonate 
• 635-93-8 5-chlorosalicyclaldehyde 
• 108-59-8 malonic acid dimethyl ester 

Relevant articles and documents

HCK INHIBITORS FOR THE TREATMENT OF FIBROSIS AND CANCER

Compounds which are thiazole and triazole derivatives are disclosed, including compounds of the following genus: Formula I. The compounds are inhibitors of hematopoietic cell kinase (HCK) and exhibit anti-fibrotic and anti-proliferative effects. They are useful in the treatment of a variety of disorders, including a fibrosis or a fibrotic disease, such as renal fibrosis.

Coumarin-3-carboxylic acid ester derivative preparation method

The invention discloses a preparation method for a coumarin-3-carboxylic ester derivative shown as the formula (I) or the formula (II) in the specification. The method comprises the step that under the existence of FeCl3 being used as a catalyst, salicylaldehyde derivative shown as the formula (III) in the specification and 2-hydroxy-1-naphthaldehyde shown as the formula (IV) in the specification are in contact reaction with alcohol and meldrum's acid which have a general formula, namely R2OH. Through the fact that the salicylaldehyde derivative, the 2-hydroxy-1-naphthaldehyde, the alcohol or the meldrum's acid is catalyzed by FeCl3 in multi-component contact reaction under a relatively temperate condition, the coumarin-3-carboxylic ester derivative with relatively high productivity is synthesized in relatively short reaction time, and the method is simple in step, efficient and environment-friendly, and completely meets the concept of green chemistry.