91069-96-4

Upstream product

• 1023-17-2 4-methoxyphenyl benzyl ketone 
• 17356-08-0 thiourea 
• 100-66-3 methoxybenzene 
• 103-80-0 phenylacetyl chloride 
• 103-82-2 phenylacetic acid 
• 1889-77-6 2-bromo-1-(4-methoxy-phenyl)-2-phenyl-ethanone 

Downstream Products

• 1429483-79-3 C₂₇H₂₂Cl₃N₃O₂S 
• 105197-15-7 4-Bromo-2-{[(E)-4-(4-methoxy-phenyl)-5-phenyl-thiazol-2-ylimino]-methyl}-phenol 
• 105197-13-5 [1-(4-Dimethylamino-phenyl)-meth-(E)-ylidene]-[4-(4-methoxy-phenyl)-5-phenyl-thiazol-2-yl]-amine 

Relevant academic research and scientific papers

Synthesis of 5-Phenylthiazolamines by Using Thiourea as an α-Bromination Shuttle

A straightforward synthesis of 5-phenylthiazolamines by coupling thiourea with phenylacetones, phenylacetophenones, and β-tetralone has been developed. Thiourea acts as a substrate and an α-bromination shuttle by transferring a Br atom from CBrCl3/s

Thiazole Compounds and Uses Thereof

The present invention relates to a compound of Formula (I), or an isomer, pharmaceutically acceptable salt and solvate thereof; the present invention further relates to a pharmaceutical composition, which comprises the compound of Formula (I), or isomer, pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents; the present invention further relates to the use of the compound of Formula (I), or isomer, pharmaceutically acceptable salt or solvate thereof, for anti-apoptosis, prophylaxis or treatment of a disease or symptom associated with apoptosis, especially for protecting myocardial cells, and prophylaxis or treatment of a disease or symptom associated with cardiomyocyte apoptosis.

SAR, cardiac myocytes protection activity and 3D-QSAR studies of salubrinal and its potent derivatives

Salubrinal is a selective inhibitor of endoplasmic reticulum (ER) stress and affords remarkable protection to cardiomyocytes. By studying the structure-activity relationship (SAR) of salubrinal, it was found that modification of the quinoline ring terminus and thiourea unit could confer the compound PP1-24 with markedly enhanced cardioprotective activity (EC 50 2 = 0.741, r2 = 0.991).

Synthesis of some Thiazole Schiff Bases and Their Derivatives

Synthesis of some Schiff bases derived from 4,5-diaryl-2-aminothiazoles have been described.Cycloaddition of the Schiff bases with thioglycolic acid gave the corresponding thiazolidone derivatives.Reaction with cyclohexanone gave the secondary amines.The compounds have been characterised by ir and mass spectra, and screened for antifungal activity.