910797-04-5

Upstream product

• 626-58-4 4-methylpiperidin 
• 300715-96-2 2-(tert-butoxycarbonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid 
• 40064-34-4 piperidine-4,4-diol hydrochloride 
• 24589-77-3 4-hydrazinobenzoic acid hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 619-67-0 4-Hydrazinobenzoic acid 
• 929345-60-8 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid 

Downstream Products

• 910801-34-2 tert-butyl 8-[(4-methylpiperidin-1-yl)carbonyl]-5-(phenylsulfonyl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate 
• 910801-39-7 tert-butyl 5-{[2-(methoxycarbonyl)phenyl]sulfonyl}-8-[(4-methylpiperidin-1-yl)carbonyl]-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate 
• 910800-08-7 tert-butyl 8-[(4-methylpiperidin-1-yl)carbonyl]-5-(4-nitrophenyl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate 
• 910800-01-0 tert-butyl 8-[(4-methylpiperidin-1-yl)carbonyl]-5-[4-(methylsulfonyl)benzyl]-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate 
• 910798-30-0 tert-butyl 5-(4-ethoxybenzyl)-8-[(4-methylpiperidin-1-yl)carbonyl]-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate 
• 910799-92-7 tert-butyl 8-[(4-methylpiperidin-1-yl)carbonyl]-5-[4-(methylthio)benzyl]-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate 
• 1361408-14-1 C₂₈H₃₃N₃O 
• 910801-35-3 C₂₄H₂₇N₃O₃S 
• 910798-31-1 5-(4-ethoxybenzyl)-8-[(4-methylpiperidin-1-yl)carbonyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 910800-09-8 8-[(4-methylpiperidin-1-yl)carbonyl]-5-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 910855-05-9 8-[(4-methylpiperidin-1-yl)carbonyl]-5-[4-(methylthio)benzyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 910800-03-2 8-[(4-methylpiperidin-1-yl)carbonyl]-5-[4-(methylsulfonyl)benzyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 910800-16-7 2-cyclopentyl-8-[(4-methylpiperidin-1-yl)carbonyl]-5-(4-nitrophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 

Relevant academic research and scientific papers

γ-Carbolines: A novel class of cannabinoid agonists with high aqueous solubility and restricted CNS penetration

An oral, peripherally restricted CB1/CB2 agonist could provide an interesting approach to treat chronic pain by harnessing the analgesic properties of cannabinoids but without the well-known central side effects. γ-Carbolines are a novel class of potent mixed CB1/CB2 agonists characterized by attractive physicochemical properties including high aqueous solubility. Optimization of the series has led to the discovery of 29, which has oral activity in a rat inflammatory pain model and limited brain exposure at analgesic doses, consistent with a lower risk of CNS-mediated tolerability issues.

NOVEL TETRAHYDRO-1H-PYRIDO [4,3-b] INDOLE DERIVATIVES AS CB1’ RECEPTOR LIGANDS

Compounds of Formulae I, or pharmaceutically acceptable salts thereof: wherein R1, R2 and R3 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.