910801-35-3

Basic information

• Product Name: C₂₄H₂₇N₃O₃S
• CAS NO: 910801-35-3
• Molecular Weight: 437.563
• Mol File: 910801-35-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₂₇N₃O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₂₇N₃O₃S(910801-35-3)
• EPA Substance Registry System: C₂₄H₂₇N₃O₃S(910801-35-3)

Safety Data

• Hazardous Substances Data: 910801-35-3(Hazardous Substances Data)

Upstream product

• 619-67-0 4-Hydrazinobenzoic acid 
• 910801-34-2 tert-butyl 8-[(4-methylpiperidin-1-yl)carbonyl]-5-(phenylsulfonyl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate 
• 910797-04-5 tert-butyl 8-[(4-methylpiperidin-1-yl)carbonyl]-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate 
• 300715-96-2 2-(tert-butoxycarbonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid 
• 929345-60-8 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid 

Relevant articles and documents

γ-Carbolines: A novel class of cannabinoid agonists with high aqueous solubility and restricted CNS penetration

An oral, peripherally restricted CB1/CB2 agonist could provide an interesting approach to treat chronic pain by harnessing the analgesic properties of cannabinoids but without the well-known central side effects. γ-Carbolines are a novel class of potent mixed CB1/CB2 agonists characterized by attractive physicochemical properties including high aqueous solubility. Optimization of the series has led to the discovery of 29, which has oral activity in a rat inflammatory pain model and limited brain exposure at analgesic doses, consistent with a lower risk of CNS-mediated tolerability issues.