91114-48-6

Upstream product

• 96-34-4 methyl chloroacetate 
• 67-56-1 methanol 
• 3261-87-8 1,4-oxathiane-2,6-dione 
• 123-93-3 thiodiacetic acid 
• 16002-29-2 dimethyl thiodiglycolate 

Relevant academic research and scientific papers

Design and Synthesis of Novel Oleanolic Acid-Linked Disulfide, Thioether, or Selenium Ether Moieties as Potent Cytotoxic Agents

A series of novel oleanolic acid (OA)-linked disulfide, thioether, or selenium ether derivatives was synthesized, and their antiproliferative activity was evaluated against human liver cancer (BEL-7402 and HepG-2), colon cancer (HCT116), and normal liver (L02) cell lines using methyl thiazolyl tetrazolium assay (MTT). Preliminary bioassay results revealed that OA derivatives modified at the C3?OH position, i. e., compound a4 containing sulfide ether, exhibited the best antiproliferative activity against BEL-7402 cells, with an IC50 value of 5.70±0.82 μM. Further flow cytometry assays revealed that compound a4 exerted its antiproliferative effects by inducing cell cycle arrest in the G2/M phase leading to apoptosis. Moreover, compared with the lead compound OA and the positive control drug 5-fluorouracil (5-FU), the OA derivatives demonstrated potent antiproliferative activities against the cancer cell lines.

PROCESS FOR PREPARING DIALKYL THIODIGLYCOLATES

A process is described for preparing alkyl thiodiglycolates of the general formula (I) [in-line-formulae]R—OOC—CH2-S—CH2-COO—R ??(I)[/in-line-formulae] where R is a radical of branched or unbranched C1 to C10-alkyl, characterized in that an alkyl haloacetate of the general formula (II) [in-line-formulae]X—CH2-COO—R ??(II)[/in-line-formulae] where X is a chlorine or bromine atom and R is as defined for compounds of the formula (I) is reacted with an aqueous solution of alkali metal sulphide or alkali metal hydrogensulphide in the presence of an aqueous pH buffer solution in the pH range between 5 and 8, optionally in the presence of a phase transfer catalyst.

Esters of Thiodiglycollic and Thiodipropionic Acids and 2,5-Dicarboxy-3,4-dihydroxythiophene as Potential Slow Acting Anticancer Agents

A series of esters of thiodiglycollic and thiodipropionic acids and 2,5-dicarboxy-3,4-dihydroxythiophene have been synthesised with a view to testing their anticancer properties.The esters, as against parent acids are expected to have a prolonged effect.