91131-79-2

Upstream product

• 30090-17-6 4-isobutylaniline 
• 544-92-3 copper(I) cyanide 
• 623-26-7 terephthalonitrile 
• 78-77-3 Isobutyl bromide 
• 538-93-2 1-phenyl-2-methylpropane 
• 10342-60-6 1-isobutyl-4-nitrobenzene 
• 557-21-1 zinc(II) cyanide 
• 2051-99-2 1-bromo-4-isobutylbenzene 

Relevant academic research and scientific papers

HETEROAROMATIC COMPOUNDS FOR USE AS HIF INHIBITORS

The present application relates to novel substituted aryl compounds, processes for their preparation, their use for treatment and/or prevention of diseases and their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be carried out as monotherapy or also in combination with other medicaments or further therapeutic measures.

Reductive Activation of Arenes. XI. Reaction of Two-Electron Reduction Product of Terephthalodinitrile with Alkyl Halides in Liquid Ammonia

The product of reduction of terephthalodinitrile with two equivalents of metallic potassium reacts with alkyl halides in liquid ammonia to yield 4-alkylbenzonitriles and 2-alkylterephthalodinitriles, whose ratio strongly depends on the alkyl halide and changes in favor of the ipso-substitution product, 4-alkylbenzonitrile, in going from tertiary alkyls to primary and from iodides to chlorides. Using cyclopropylmethyl bromide as model alkylating agent, the reaction was shown to proceed by concurrent nucleophilic substitution (SN) and electron transfer (ET) mechanisms. Change in the product ratio is the result of increased contribution of the SN mechanism.