911372-66-2Relevant academic research and scientific papers
Method for synthesizing chiral amine
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Paragraph 0042; 0043; 0044; 0045, (2019/01/16)
The invention discloses a method for synthesizing chiral amine. According to the method, a catalytic amount of ketone is used as a self-catalyst, alkali which is cheap and easy to get is used as a synergistic catalyst, a 1-aryl-alcoho compound is used as
From racemic alcohols to enantiopure amines: Ru-catalyzed diastereoselective amination
Oldenhuis, Nathan J.,Dong, Vy M.,Guan, Zhibin
supporting information, p. 12548 - 12551 (2014/12/10)
A commercially available ruthenium(II) PNP-type pincer catalyst (Ru-Macho) promotes the formation of α-chiral tert-butanesulfinylamines from racemic secondary alcohols and Ellmans chiral tert-butanesulfinamide via a hydrogen borrowing strategy. The formation of α-chiral tert-butanesulfinylamines occurs in yields ranging from 31% to 89% with most examples giving >95:5 dr.
Reversal of diastereofacial selectivity in hydride reductions of N-tert-butanesulfinyl imines
Colyer, John T.,Andersen, Neil G.,Tedrow, Jason S.,Soukup, Troy S.,Faul, Margaret M.
, p. 6859 - 6862 (2007/10/03)
A variety of N-tert-butanesulfinyl imines were reduced with NaBH 4 in THF containing 2% water to provide the corresponding secondary sulfinamides in high yield and diastereoselectivity. By using the same sulfinyl imine starting materials and changing the reductant to L-Selectride, the stereoselectivity could be efficiently reversed to afford the opposite product diastereomer in high yield and selectivity.
