911398-53-3

Upstream product

• 764722-84-1 5-Bromo-thiophene-2-carboxylic acid [(S)-1-((R)-3-amino-pyrrolidine-1-carbonyl)-pyrrolidin-3-yl]-methyl-amide 
• 4255-62-3 4,4-dimethylcyclohexane-1-one 
• 169750-00-9 (S)-1-benzyl-3-[[N-(t-butoxycarbonyl)]-N-methylamino]pyrrolidine 
• 764722-45-4 3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidine-1-carboxylic acid 4-nitro-phenyl ester 
• 764722-66-9 2,2,2-Trifluoro-N-[(R)-1-((S)-3-methylamino-pyrrolidine-1-carbonyl)-pyrrolidin-3-yl]-acetamide 
• 764722-65-8 Methyl-{(S)-1-[(R)-3-(2,2,2-trifluoro-acetylamino)-pyrrolidine-1-carbonyl]-pyrrolidin-3-yl}-carbamic acid tert-butyl ester 
• 764722-83-0 5-Bromo-thiophene-2-carboxylic acid methyl-{(S)-1-[(R)-3-(2,2,2-trifluoro-acetylamino)-pyrrolidine-1-carbonyl]-pyrrolidin-3-yl}-amide 
• 7311-63-9 5-bromothiophene-2-carboxylic acid 
• 169749-99-9 (3S)-(-)-1-benzyl-3-(methylamino)pyrrolidine 
• 169750-01-0 (S)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2

The design, synthesis, and SAR of a series of retro bis-aminopyrrolidine ureas are described. Compounds from this series exhibited considerable binding affinity (Ki = 1 nM) and functional activity at MCH-R1, acceptable CYP2D6 inhibition, and good rat brain exposure.