911411-54-6

Basic information

• Product Name: (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methylpropionitrile
• Synonyms: (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methylpropionitrile
• CAS NO: 911411-54-6
• Molecular Weight: 258.243
• Mol File: 911411-54-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methylpropionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methylpropionitrile(911411-54-6)
• EPA Substance Registry System: (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methylpropionitrile(911411-54-6)

Safety Data

• Hazardous Substances Data: 911411-54-6(Hazardous Substances Data)

Upstream product

• 911411-78-4 (2R,2S)-2-methyl-4-(R)-phenyl-2-(trifluoromethyl)oxazolidine 
• 56613-80-0 D-2-phenylglycinol 
• 20989-17-7 Phenylglycinol 
• 7677-24-9 trimethylsilyl cyanide 
• 1202059-62-8 (2S,4R)-2-methyl-4-phenyl-2-trifluoromethyl-1,3-oxazolidine 
• 911411-43-3 ((E)-2,2,2-trifluoro-1-methylethylidene)((1R)-2-hydroxy-1-phenylethyl)amine 

Downstream Products

• 102210-02-6 (R)-(+)-3,3,3-trifluoro-2-amino-2-methylpropianoic acid 
• 911411-83-1 methyl (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methylpropionate 
• 911411-86-4 (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methyl-propylamine 

Relevant articles and documents

Pyrimidinone Derivatives as Antimalarial Agents

The invention relates to novel pyrimidinone-based heterocyclic compounds which are parasite growth inhibitors, having the general formula (I) in which Y is a morpholine chosen from three bridged morpholines, L is a bond or a linker, n=0 or 1 and R2 is a methyl group when n=0 and a hydrogen atom when n=1. Process for the preparation thereof and therapeutic use thereof.

A convenient one-pot synthesis of (R)-2-amino-3,3,3-trifluoro-2-methyl-N- phenylpropanamide derivatives

A convenient one-pot synthesis of enantiopure (R)-2-amino-3,3,3-trifluoro- 2-methyl-N-phenylpropanamide derivatives has been developed. The key step in this synthetic methodology turned out to be the amide formation in which (R)-2-amino-3,3,3-trifluoro-2-

NOVEL 2,3-DIHYDRO-1H-IMIDAZO{1,2-a}PYRIMIDIN-5-ONE and this1,2,3,4-TETRAHYDROPYRIMIDO{1,2-a}PYRIMIDIN-6-ONE DERIVATIVES COMPRISING A SUBSTITUTED MORPHOLINE, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF

The invention relates to the novel products of formula (I) with p, q = 0, 1 or 2; R1 = phenyl, pyridyl; -(CH2) m -Ra; alkylene; cycloalkyl; heterocycloalkyl; alkyl; -SO2 -Rb; -CO-Re; m = 1 or 2; Ra = aryl, heteroaryl, -CO-cycloalkyl, -CO-heterocycloalkyl, -CO-Rb, -C(Rb)=N-ORc, -CO 2 Rd, -CONRxRy; Rb = alkyl, aryl, heteroaryl; Rc = H, alkyl; Rd = alkyl, cycloalkyl; Re = alkyl, cycloalkyl, aryl, heteroaryl; NRxRy with Rx,Ry = H, alkyl, cycloalkyl, alkoxy, phenyl, or form with N a ring with optionally O, N; R2, R3 = H, alkyl, CF 3, or form with C a ring with optionally O, S and N; R4 = H, F, Cl, CH3 or CN; the morpholine is substituted with Me, and optionally substituted with F, OH; or is (Formula 1a) and the isomer of configuration R,R (Formula 1b) these products being in all the isomer forms and the salts, as medicaments, in particular as anticancer medicaments.