91497-60-8

Upstream product

• 5445-17-0 Methyl 2-bromopropionate 
• 17639-93-9 2-chloro-propionic acid methyl ester 
• 99-93-4 4-Hydroxyacetophenone 
• 108-95-2 phenol 
• 2065-24-9 methyl 2-phenoxypropanoate 
• 75-36-5 acetyl chloride 

Downstream Products

• 91143-71-4 (RS)-2-(4-acetylphenoxy)propionic acid 
• 60075-04-9 (RS)-methyl 2-(4-hydroxyphenoxy)propionate 

Relevant academic research and scientific papers

Synthesis and biological evaluation of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists

Free fatty acid receptor 1 (FFA1) is a new potential drug target for the treatment of type 2 diabetes because of its role in amplifying glucose-stimulated insulin secretion in pancreatic β-cell. In the present studies, we identified phenoxyacetic acid derivative (18b) as a potent FFA1 agonist (EC50 = 62.3 nM) based on the structure of phenylpropanoic acid derivative 4p. Moreover, compound 18b could significantly improve oral glucose tolerance in ICR mice and dose-dependently reduced glucose levels in type 2 diabetic C57BL/6 mice without observation of hypoglycemic side effect. Additionally, compound 18b exhibited acceptable PK profiles. In summary, compound 18b with ideal PK profiles exhibited good activity in vitro and in vivo, and might be a promising drug candidate for the treatment of diabetes mellitus.

Synthesis of 2-(4-hydroxyphenoxy) alkanoic acid esters

A method for synthesizing 2-(4-hydroxyphenoxy)alkanoic acid esters by reacting a hydroxyaromatic ketone derivative with a 2-substituted alkanoic acid ester under basic conditions and thereafter oxidizing the intermediate with subsequent hydrolysis.

Process for the preparation of D(+)-2-(4-acetylphenoxy)-propionic esters

Process for the preparation of D(+)-2-(4-acetylphenoxy)-propionic esters Preparation of D(+)-2-(4-acetylphenoxy)-propionic esters of the formula STR1 by reacting 4-hydroxyacetophenone with L-halo- or sulfonyloxy-lactic esters in a basic medium at temperatures ≤50° C.

Synthesis of 2-(4-hydroxyphenoxy)alkanoic acids

A method for synthesizing 2-(4-hydroxyphenoxy)alkanoic acids by reacting a hydroxyaromatic ketone derivative with a 2-substituted alkanoic acid under basic conditions and thereafter oxidizing the intermediate with subsequent hydrolysis.

Synthesis of 2-(4-aminophenoxy)alkanoic acids and esters and their derivatives

A method for synthesizing 2-(4-amidophenoxy)alkanoic acids and esters and 2-(4-aminophenoxy)alkanoic acids and esters by reacting a hydroxyaromatic ketone derivative with a 2-substituted alkanoic acid or ester under basic conditions and thereafter reactin