911461-03-5Relevant academic research and scientific papers
Novel tricyclic poly (ADP-ribose) polymerase-1/2 inhibitors with potent anticancer chemopotentiating activity: Design, synthesis and biological evaluation
Li, Hui,Hu, Yan,Wang, Xueyan,He, Guangwei,Xu, Yungen,Zhu, Qihua
, p. 4731 - 4740 (2016)
8,9-Dihydro-2,4,7,9a-tetraazabenzo[cd]azulen-6(7H)-ones were designed and synthesized as a new class of PARP-1/2 inhibitors. The compounds displayed a variable pattern of PARP-1/2 enzymes inhibition profile that, in part, paralleled the antiproliferative
Design, synthesis and biological evaluation of novel imidazo[4,5-c] pyridinecarboxamide derivatives as PARP-1 inhibitors
Zhu, Qihua,Wang, Xuyan,Chu, Zhaoxing,He, Guangwei,Dong, Guangping,Xu, Yungen
, p. 1993 - 1996 (2013/04/24)
A series of novel cyclic amine-substituted imidazo[4,5-c] pyridinecarboxamide analogs were designed and synthesized. All the target compounds were evaluated for their PARP inhibition activity, and the result indicated that most of the compounds possessed
Transformations of ortho-methoxyaryl(hetaryl)carboxamides into quinazolin-4-one and pyrido[2,3-d]pyrimidin-4-one derivatives
Ryabova,Makarov,Alekseeva,Shashhov,Chernyshev,Granik
, p. 1907 - 1914 (2007/10/03)
ortho-Chloroaryl(hetaryl)carboxamides containing one or two nitro groups at positions 3 and/or 5 of the ring undergo condensation accompanied by the pyrimidine ring closure on refluxing in an excess of sodium methoxide to form bicyclic products, viz., qui
