911482-75-2Relevant academic research and scientific papers
Construction of multiple, contiguous quaternary stereocenters in acyclic molecules by lithiation-borylation
Watson, Charlotte G.,Balanta, Angelica,Elford, Tim G.,Essafi, Stphanie,Harvey, Jeremy N.,Aggarwal, Varinder K.
supporting information, p. 17370 - 17373 (2015/02/05)
Lithiation of carbamates followed by borylation provides a powerful method for the homologation of boron reagents. However, when applied to hindered systems (secondary carbamates with tBu-boronic esters) for the construction of two quaternary centers, thi
Practical and efficient applications of novel dioxaborolanes and dioxaborinanes in the synthesis of corresponding boronates and their use in the palladium-catalyzed cross coupling reactions
Myslinska, Malgorzata,Heise, Glenn L.,Walsh, Dana J.
experimental part, p. 2937 - 2941 (2012/07/31)
The syntheses of boronates derived from the reaction of dioxaborolanes and dioxaborinanes with either organolithium or organomagnesium reagents are investigated along with their subsequent use in the palladium cross coupling reaction. The intrinsic stability of these cyclic esters contributes to their facile reaction with both lithium and magnesium nucleophiles at mild and safe conditions. We have found that many of the reactions proceed at room temperature which is a significant improvement over the traditional routes which require cryogenic temperatures. The scope of these reactions and their practical application to large scale process synthesis is described.
NOVEL BORATE DERIVATIVES AND THEIR APPLICATIONS
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Page/Page column 6, (2012/12/13)
Borates, compositions comprising chiral (cyclic and acyclic) and achiral (cyclic and acyclic) borates; chiral (cyclic and acyclic) and achiral (cyclic and acyclic) biborates; and methods for their synthesis. Additionally, a significantly improved synthetic protocol for the synthesis of wide range of boronates starting from borates or biborates and Grignard or organolithium reagents that can be used for kilo lab and commercial scale production.
