62108-06-9

Basic information

• Product Name: 2-Allyl-2-hexanol
• Synonyms: 2-Allyl-2-hexanol;4-Methyl-1-octen-4-ol;4-methyloct-1-en-4-ol
• CAS NO: 62108-06-9
• Molecular Formula: C9H18O
• Molecular Weight: 142.23862
• Product Categories: Aliphatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 62108-06-9.mol
• Article Data: 20

Chemical Properties

• Melting Point: -7°C (estimate)
• Boiling Point: 224.85°C (estimate)
• Appearance: /
• Density: 0.8660 (estimate)
• Refractive Index: 1.4391 (estimate)
• Storage Temp.: -20°C Freezer
• Solubility: DCM, Ethyl Acetate
• CAS DataBase Reference: 2-Allyl-2-hexanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Allyl-2-hexanol(62108-06-9)
• EPA Substance Registry System: 2-Allyl-2-hexanol(62108-06-9)

Safety Data

• Hazardous Substances Data: 62108-06-9(Hazardous Substances Data)

Usage

Uses

4-Methyl-1-octen-4-ol is an intermediate in the synthesis of Misoprostol (M368755), an cytoprotective prostaglandin PGE analogue.

Synthesis Reference(s)

Tetrahedron Letters, 30, p. 7149, 1989 DOI: 10.1016/S0040-4039(01)93920-6

Upstream product

• 591-78-6 n-hexan-2-one 
• 191732-48-6 (E)-(3-bromoprop-1-en-1-yl)tributylstannane 
• 24850-33-7 allyltributylstanane 
• 2622-05-1 allylmagnesium bromide 
• 911482-75-2 allylboronic acid 2,2-dimethyl-1,3-propanediol ester 
• 107-05-1 3-chloroprop-1-ene 
• 106-95-6 allyl bromide 
• 127700-08-7 [2-(1-Allyl-1-methyl-pentyloxymethoxy)-ethyl]-trimethyl-silane 
• 556-56-9 allyl iodid 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 64549-05-9 allyldibutyltin chloride 
• 109-72-8 n-butyllithium 
• 36219-40-6 1-bromo-2-hydroxy-2-methyl-3-butene 
• 693-03-8 n-butyl magnesium bromide 

Downstream Products

• 29839-53-0 5-butyl-5-methyl-tetrahydro-furan-3-ol 

Relevant articles and documents

ALLYL BUTYLTIN HALIDES (CH2=CHCH2)SnBu3-nCln(n=0, 1, 2, 3). PREPARATION, CARBON-13NMR CHARACTERISATION AND ALLYLSTANNYLATION ABILITY TOWARDS KETONES AND ALDEHYDES

Mixed allylbutyltin halides (CH2=CHCH2)SnBu3-nCln (n=0-3) have been prepared, and characterized by carbon-13 NMR spectroscopy.Their ability to bring about allylstannylation of ketones and aldehydes, to form organostannoxy compounds, Bu3-nSnClnOC(R')(R'')CH2CH=CH2, has been shown to increase on increasing the value of n, that is on increasing the acceptor ability of the tin centre.

Lewis acid catalyzed synthesis of cyclic carbonates, precursors of 1,2- and 1,3-diols

An eco-friendly synthesis of cyclic carbonates through a Lewis acid catalyzed cyclization of tert-butyl carbonates is described. These cyclic carbonates are precursors of 1,2- and 1,3-diols, and the developed method was applied to a short synthesis of a diarylheptanoid, (3S,5S)-alpinikatin.

SnCl2·2H2O-mediated Barbier-type allylation: A comparative evaluation of the catalytic performance of CuI and Pd(OAc) 2

A systematic investigation has been carried out for the allylation of carbonyl compounds under SnCl2·2H2O-mediated Barbier-type conditions, using CuI and Pd(OAc)2 as catalysts. Ketones, which are not reactive under the influence of CuI, however, could be activated by using Pd(OAc)2 as a catalyst.