911682-17-2Relevant articles and documents
Suppression of inducible nitric oxide synthase expression by yakuchinones and their analogues
Lee, Hwa Jin,Kim, Ji Sun,Yoon, Joung Wha,Kim, Hee-Doo,Ryu, Jae-Ha
, p. 377 - 379 (2007/10/03)
Analogues of yakuchinones were synthesized as inhibitors of nitric oxide production in lipopolysaccharideactivated macrophage cell line, RAW 264.7 cells. We prepared stronger inhibitors than the original natural molecules, yakuchinones A and B reported from Alpinia oxyphylla. From the limited structural activity relation study of analogues, we concluded that the optimal length of linker between two aryl groups and the presence of enone moiety in the linker were identified as essential for the activity. The IC50 value of the most potent structure was 0.92 μM. The active analogues suppressed the expression of inducible nitric oxide synthase protein and mRNA.
Chain-branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists
Yoon, JungWha,Choi, HyeYoung,Lee, Hyun Joo,Ryu, Chong Hyun,Park, Hyeung-Geun,Suh, Young-Ger,Oh, Uhtaek,Jeong, Yeon Su,Choi, Jin Kyu,Park, Young-Ho,Kim, Hee-Doo
, p. 1549 - 1552 (2007/10/03)
A series of acyclic phenethylthiocarbamate derivatives have been synthesized, and their antagonist effect against vanilloid receptor tested. Chain branching led to a significant change in antagonist activity of the parent molecule. Ethyl-branched 1e showe