911682-17-2

Upstream product

• 290820-47-2 (2E)-3-[4-[[tert-butyldimethylsilyl]oxy]-3-methoxyphenyl]acrylaldehyde 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 75-16-1 methylmagnesium bromide 
• 458-36-6 trans-coniferyl aldehyde 

Downstream Products

• 590365-90-5 phenethyl-thiocarbamic acid O-{3-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-1-methyl-propyl} ester 
• 122-48-5 4-(4-hydroxy-3-methoxyphenyl)-2-butanone 
• 1080-12-2 (E)-4-(4-hydroxy-3-methoxyphenyl)but-3-ene-2-one 
• 911682-18-3 4-(4-((tert-butyldimethylsiloxy)-methyl)-3-methoxyphenyl)-but-3-ene-2-one 
• 590365-85-8 4-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-phenyl]-butan-2-ol 

Relevant academic research and scientific papers

Suppression of inducible nitric oxide synthase expression by yakuchinones and their analogues

Analogues of yakuchinones were synthesized as inhibitors of nitric oxide production in lipopolysaccharideactivated macrophage cell line, RAW 264.7 cells. We prepared stronger inhibitors than the original natural molecules, yakuchinones A and B reported from Alpinia oxyphylla. From the limited structural activity relation study of analogues, we concluded that the optimal length of linker between two aryl groups and the presence of enone moiety in the linker were identified as essential for the activity. The IC50 value of the most potent structure was 0.92 μM. The active analogues suppressed the expression of inducible nitric oxide synthase protein and mRNA.

Chain-branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists

A series of acyclic phenethylthiocarbamate derivatives have been synthesized, and their antagonist effect against vanilloid receptor tested. Chain branching led to a significant change in antagonist activity of the parent molecule. Ethyl-branched 1e showe