911697-25-1

Basic information

• Product Name: (2R,4R)-4-amino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid dimethyl ester
• CAS NO: 911697-25-1
• Molecular Weight: 292.335
• Mol File: 911697-25-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2R,4R)-4-amino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4R)-4-amino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid dimethyl ester(911697-25-1)
• EPA Substance Registry System: (2R,4R)-4-amino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid dimethyl ester(911697-25-1)

Safety Data

• Hazardous Substances Data: 911697-25-1(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 911697-23-9 (R)-7-Benzyl-2,4-dioxo-1,3,7-triaza-spiro[4.4]nonane-8-carboxylic acid ethyl ester 
• 2584-71-6 cis-hydroxy-D-proline 
• 171192-72-6 (2R,4R)-ethyl N¹-benzyl-4-hydroxypyrrolidine-2-carboxylate 
• 171192-74-8 (2R)-ethyl N¹-benzyl-4-oxopyrrolidine-2-carboxylate 
• 100-39-0 benzyl bromide 
• 132666-67-2 (2S,4R)-ethyl 4-hydroxypyrrolidine-2-carboxylate 
• 171336-76-8 (2R,4R) 4-amino-1-(benzyl)-pyrrolidine-2,4-dicarboxylic acid 

Relevant articles and documents

Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): Identification of a new group III metabotropic glutamate receptor selective agonist

A new family of mGlu receptor orthosteric ligands called APTCs was designed and synthesized using a parallel chemistry approach. Amongst 65 molecules tested on mGlu4, mGlu6 and mGlu8 subtypes, (2S,4S)-4-amino-1-[(E)-3-carboxyacryloyl]pyrrolidine-2,4-dicar

1-amino-APDC, a partial agonist of group II metabotropic glutamate receptors with neuroprotective properties

The synthesis of the 1-amino derivative of (2R,4R)-4-aminopyrrolidine- 2,4-dicarboxylic acid (1-amino-APDC), a selective metabotropic glutamate ligand, is disclosed. This compound acts as a partial agonist of the group II mGluRs and shows pronounced neuroprotective properties in the NMDA model of cell toxicity.