911705-46-9

Upstream product

• 911705-48-1 [(S)-4-(4-methoxy-phenyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 5720-07-0 4-methoxyphenylboronic acid 
• 911705-51-6 (S)-4-(4-methoxy-phenyl)-6-oxo-3,6-dihydro-2H-pyridine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester 
• 911705-50-5 (S)-4-(4-methoxy-phenyl)-6-oxo-1,2,3,6-tetrahydro-pyridine-2-carboxylic acid benzyl ester 

Downstream Products

• 911705-44-7 (3R,4R,6S)-6-hydroxymethyl-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-piperidin-3-ol 

Relevant academic research and scientific papers

Organic compounds

The present invention relates to substituted piperidines of the general formula (I), where R1, R2, R3, R4, R5, Q and X have the definitions elucidated in more detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors. Moreover, the enzymatic substrate portion of the compound is simultaneously a substrate for a membrane transporter.

Substituted piperidines as inhibitors of beta-secretase, cathepsin D, plasmepsin II and/or HIV protease

Use of compounds of the general formula (I) or (II) and pharmaceutically acceptable salt thereof, in which R, R1, R2, R3, R4, Q, W, X and Z, n and m have the definitions illustrated in detail in the description,

SUBSTITUTED PIPERIDINES

SP-P2140 ATE - 132 - Abstract Novel substituted piperidines of the general formula (I) and (II) with the substituent definitions as explained in detail in the description are described. The compounds are suitable in particular as renin inhibitors and are