91177-27-4

Usage

Uses

Used in Pharmaceutical Industry:
Piperacillin is used as an antibiotic for the treatment of a wide range of bacterial infections, including urinary tract infections, respiratory infections, and skin infections. Its broad-spectrum activity and effectiveness against multi-drug resistant bacteria make it a valuable asset in the fight against bacterial infections.
Used in Combination Therapy:
Due to the emergence of antibiotic-resistant bacteria, piperacillin is often used in combination with a beta-lactamase inhibitor, such as tazobactam, to enhance its activity and extend its spectrum of action. This combination therapy helps to overcome resistance mechanisms and improve the effectiveness of treatment against a broader range of bacterial infections.
Used in Hospital Settings:
Piperacillin is commonly used in hospital settings for the treatment of severe or life-threatening bacterial infections, particularly in intensive care units and other high-risk environments. Its broad-spectrum activity and ability to combat multi-drug resistant bacteria make it a crucial component of hospital antibiotic protocols.
Used in Research and Development:
As a semisynthetic penicillin derivative, piperacillin is also used in research and development for the discovery of new antibiotics and the study of bacterial resistance mechanisms. Understanding the properties and mechanisms of action of piperacillin can contribute to the development of more effective and targeted antibiotic therapies in the future.

Upstream product

• 67977-95-1 diphenylmethyl 6β-(4-toluamido)penicillate 1-oxide 
• 104101-66-8 diphenylmethyl 6β-(4-toluamido)penicillanate 
• 91-01-0 1,1-Diphenylmethanol 
• 68313-81-5 diphenylmethyl (2R,6R,7R)-3-methylene-7-[(4-methylbenzoyl)amino]-8-oxo-5-oxa-1-azabicyclo[4.2.0]octane-2-carboxylate 
• 67978-05-6 C₂₉H₂₆N₂O₄ 
• 82468-41-5 C₂₉H₂₈N₂O₅S 
• 17028-66-9 6β-(4-toluamido)penicillanic acid 

Downstream Products

• 1370637-62-9 C₁₇H₁₈F₂N₃O₆S⁽¹⁺⁾*I^(1-) 
• 134237-56-2 (6R,7R)-benzhydryl (7-(2-difluoromethylthio)acetamido)-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4,2,0]oct-2-ene-2-carboxylate 
• 1370637-72-1 C₃₀H₂₆Cl₂N₂O₆S 
• 1370637-75-4 C₃₀H₂₅Cl₃N₂O₆S 
• 1370637-57-2 C₃₀H₂₈F₂N₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-79-8 C₃₃H₃₂F₂N₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-82-3 C₃₁H₂₈F₂N₅O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-86-7 C₃₅H₃₁ClN₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-89-0 C₃₈H₃₅ClN₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-91-4 C₃₆H₃₁ClN₅O₆S⁽¹⁺⁾*I^(1-) 
• 1370638-03-1 C₂₀H₂₂F₂N₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-94-7 C₃₅H₃₀Cl₂N₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-97-0 C₃₈H₃₄Cl₂N₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370638-00-8 C₃₆H₃₀Cl₂N₅O₆S⁽¹⁺⁾*I^(1-) 

Relevant academic research and scientific papers

Preparation method of oxacephem mother nucleus

The invention discloses a preparation method of oxacephem mother nucleus. the method comprises the following steps: using a compound (I) as a raw material, firstly carrying out an oxidization reactionbetween the compound (I) and peroxide in an organic solvent, then letting the reaction product react with sodium thiosulfate, extracting a dichloromethane phase after the reaction, carrying out negative pressure distillation, and adding a crystallization solvent to obtain the final product oxacephem mother nucleus. The preparation method of the oxacephem mother nucleus has the following advantages: the preparation operation is simple; the raw materials for the preparation are cheap and easily available; the preparation cost is low; the reaction route is short; molar yield is high; the preparation method is easy for industrialization; and the purity of the prepared finished product (HPLC) can reach 99%.

Synthesis method of oxacephem nucleus

The invention discloses a synthesis method of oxacephem nucleus. The method comprises the steps: dissolving 1-oxycephalosporin-3-methylene (001) as a raw material by taking dichloromethane as a solvent, then, slowly introducing hydrogen chloride and oxygen after the raw material is dissolved, ending a reaction, regulating the pH value of a reaction feed liquid to 5.0-7.0 by using a sodium hydrogencarbonate solution with the mass percentage being 5%, carrying out extraction to obtain a dichloromethane phase, carrying out reduced pressure distillation, then, adding a crystal solvent to obtain oxacephem nucleus serving as a final product. The synthesis method disclosed by the invention is short in step, easy to realize, capable of omitting chlorine serving as a hazardous gas, little in environment pollution, high in process safety, high in product mole yield reaching up to 97% and suitable for industrial production.

Design, synthesis and antibacterial activity of novel 1-oxacephem analogs

A series of 1-oxacephem analogs were synthesized and their antibacterial properties against five strains of Gram-positive and Gram-negative bacteria were evaluated in vitro while ceftazidine was selected as control. Some of the tested compounds, compound 12c in particular, showed more active against three selected strains than the standard.