91181-95-2Relevant articles and documents
Discovery of novel and ligand-efficient inhibitors of plasmodium falciparum and plasmodium vivax N-myristoyltransferase
Rackham, Mark D.,Brannigan, James A.,Moss, David K.,Yu, Zhiyong,Wilkinson, Anthony J.,Holder, Anthony A.,Tate, Edward W.,Leatherbarrow, Robin J.
supporting information, p. 371 - 375 (2013/02/23)
N-Myristoyltransferase (NMT) is an attractive antiprotozoan drug target. A lead-hopping approach was utilized in the design and synthesis of novel benzo[b]thiophene-containing inhibitors of Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) NMT. These inhibitors are selective against Homo sapiens NMT1 (HsNMT), have excellent ligand efficiency (LE), and display antiparasitic activity in vitro. The binding mode of this series was determined by crystallography and shows a novel binding mode for the benzothiophene ring.
Synthesis of benzofuran analogs of fenamates as non steroidal antiinflammatory agents
Mane, Balasaheb Y.,Agasimundin,Shivakumar
scheme or table, p. 264 - 269 (2010/11/04)
A series of benzofuran analogs of anthranilic acid derivatives are synthesized. All the new compounds have been characterized by spectral data and elemental analyses and screened for antiinflammatory activity. Compounds 3e, 4e, 4g and 5g are found to poss
