56424-76-1

Upstream product

• 67-56-1 methanol 
• 635-53-0 (2-carboxyphenoxy)acetic acid 
• 96-32-2 bromoacetic acid methyl ester 
• 119-36-8 methyl salicylate 
• 6280-80-4 2-Formylphenoxyacetic acid 
• 96-34-4 methyl chloroacetate 
• 69-72-7 salicylic acid 

Downstream Products

• 91181-95-2 3-hydroxy-benzofuran-2-carboxylic acid ethyl ester 
• 5117-55-5 methyl 3-hydroxybenzofuran-2-carboxylate 
• 635-53-0 (2-carboxyphenoxy)acetic acid 
• 113496-10-9 2-(2-(methoxycarbonyl)phenoxy)acetic acid 

Relevant academic research and scientific papers

Microwave-Assisted Synthesis of Benzofuran-3(2H)-ones

A new method for the synthesis of benzofuran-3(2H)-ones under microwave conditions was developed. The reaction conditions were screened, and the scope of benzoate substrates was investigated. The results showed that our method could provide rapid access to these important dihydrobenzofuranones in 43% to 58% yields.

Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity

Several benzofuran derivatives linked to a 3-indoletetrahydropyridine through an alkyl chain were prepared and evaluated for serotonin transporter and 5-HT1A receptor affinities. Their design, synthesis and structure-activity relationships are described.

FUNCTIONALIZED PHENOLIC COMPOUNDS AND POLYMERS THEREFROM

The present invention relates to compounds of formula I, which are functionalized phenolic compounds, and polymers formed from the same. Ar—[O—(X)p—R′]q??I Polymers formed from the functionalized phenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.

Functionalized drugs and polymers derived therefrom

Compounds selected from: where DRUG-OH, DRUG-COOH and DRUG-NH2 are biologically active compounds; each X is independently selected from —CH2COO— (glycolic acid moiety), —CH(CH3)COO— (lactic acid moiety), —CH2CH2OCH2COO— (dioxanone moiety), —CH2CH2CH2CH2CH2COO— (caprolactone moiety), —(CH2)yCOO—, where y is 2-4 or 6-24 and —(CH2CH2O)zCH2COO—, where z is 2-24; each Y is independently selected from —COCH2O— (glycolic ester moiety), —COCH(CH3)O— (lactic ester moiety), —COCH2OCH2CH2O— (dioxanone ester moiety), —COCH2CH2CH2CH2CH2O— (caprolactone ester moiety), —CO(CH2)mO—, where m is 2-4 or 6-24 and —COCH2O(CH2CH2O)n— where n is between 2-24; R′ is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; and p is 1-6. Multi-functional compounds and drug dimers, oligomers and polymers are also disclosed.

A simple method for the preparation of monomethyl esters of dicarboxylic acids by selective esterification of the nonconjugated carboxyl group in the presence of an aromatic or conjugated carboxyl group

Various dicarboxylic acids have been converted selectively into monomethyl esters in which the nonconjugated carboxyl group is selectively esterified in the presence of an aromatic or conjugated carboxyl group at room temperature (~ 25-27°C) in methanol using a catalytic amount of thionyl chloride.

Use of Phosphorus Pentoxide. Preparation of Half-esters through Selective Esterification

Methyl 2-,3-,4-carboxyphenylacetate and methyl 2-,3-,4-carboxyphenoxyacetate have been prepared through selective esterification of the aliphatic carboxylic acid function of the corresponding dicarboxylic acids using a mixture of phosphorus pentoxide (1 part), anhydrous copper sulphate (5 parts) and anhydrous sodium sulphate (5 parts).All the isomeric half-esters have been prepared through partial hydrolysis of the corresponding dimethylesters.

Naturally Occurring Dibenzofurans. Part 4. Synthesis of Dibenzofurandiols by Annelation of Benzofurans

Methyl 3-acetylbenzofuran-2-ylacetate (8) undergoes C-methylation affording methyl 2-(3-acetylbenzofuran-2-yl)propionate (13).These compounds and similar oxo esters undergo ready cyclization to dibenzofurandiols on treatment with sodium methoxide in boiling methanol.A convenient synthesis of dimethyl furan-2,5-diylacetate (30) is described, as are attempts to synthesize 1,3,7,9-tetramethoxy-2,8-dimethyldibenzofuran (3).