ethyl 3-hydroxybenzofuran-2-carboxylate

Base Information

• Chemical Name: ethyl 3-hydroxybenzofuran-2-carboxylate
• CAS No.: 91181-95-2
• Molecular Formula: C₁₁H₁₀O₄
• Molecular Weight: 206.198
• Mol file: 91181-95-2.mol

Synonyms:3-hydroxy-benzofuran-2-carboxylic acid ethyl ester

Chemical Property of ethyl 3-hydroxybenzofuran-2-carboxylate

Chemical Property:

• Melting Point: 70.5-71.5 °C
• Boiling Point: 300.9±22.0 °C(Predicted)
• PKA: 7.20±0.50(Predicted)
• Density: 1.295±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

3-Hydroxy-benzofuran-2-carboxylicacidethylester 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of ethyl 3-hydroxybenzofuran-2-carboxylate

There total 8 articles about ethyl 3-hydroxybenzofuran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl 2-(2-ethoxy-2-oxoethoxy)benzoate (56424-77-2) → 3-hydroxy-benzofuran-2-carboxylic acid ethyl ester (91181-95-2)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.283333h;

DOI:10.1021/jm301474t

Reference yield: 40.0%

methyl <(2-methoxycarbonyl)phenoxy>acetate (56424-76-1) + magnesium ethylate (2414-98-4) → 3-hydroxy-benzofuran-2-carboxylic acid ethyl ester (91181-95-2)

Guidance literature:

In ethanol; at 78 ℃; for 1.5h;

DOI:10.1135/cccc19930592

Reference yield:

2-hydroxy-benzoic acid ethyl ester (118-61-6) → 3-hydroxy-benzofuran-2-carboxylic acid ethyl ester (91181-95-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 3 h / 60 °C

2: potassium tert-butylate / tetrahydrofuran / 0.28 h / 20 °C

With potassium tert-butylate; potassium carbonate; In tetrahydrofuran; acetone; 1: |Williamson Ether Synthesis / 2: |Dieckmann Condensation;

DOI:10.1021/jm301474t

upstream raw materials:

ethyl 2-(2-ethoxy-2-oxoethoxy)benzoate

potassium ethoxide

methyl <(2-methoxycarbonyl)phenoxy>acetate

magnesium ethylate

Downstream raw materials:

C₁₇H₁₃ClFNO₃

ethyl 3-p-toluidinobenzofuran-2-carboxylate

C₁₇H₁₄ClNO₃

C₁₅H₁₀ClNO₃

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