91182-06-8

Upstream product

• 2621-73-0 ethyl 4-nitrophenylcarbamate 
• 51028-38-7 (4-nitro-phenyl)-carbamoyl chloride 
• 100-01-6 4-nitro-aniline 
• 543-27-1 isobutyl chloroformate 
• 78-83-1 2-methyl-propan-1-ol 
• 100-28-7 4-Nitrophenyl isocyanate 

Downstream Products

• 132755-71-6 isobutyl N-<4-nitro-2-(phthalidomethyl)phenyl>carbamate 
• 132755-75-0 isobutyl N-(4-nitrophenyl)-N-(phthalimidomethyl)carbamate 
• 1019455-18-5 (4-amino-phenyl)-carbamic acid isobutyl ester 

Relevant academic research and scientific papers

Diaminopuridine-containing thiourea inhibitors of herpes viruses

Compounds of the formula STR1 are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.

The Phthalimidomethyl Rearrangement

The discovery of a new acid-catalysed monodentate N -> C aromatic rearrangement, namely the phthalimidomethyl rearrangement, is reported.In this rearrangement, discovered during the reaction of N-hydroxymethylphthalimide with certain alkyl N-(4-nitrophenyl)carbamates in concentrated sulfuric acid solution, the phthalimidomethyl group migrates from its initial location on the nitrogen atom of the carbamate function to a carbon atom of the nitrophenyl group.Evidence, provided by an appropriate 'crossover' experiment, indicates that the rearrangement is intermolecular.Hindered rotation about the N(carbamoyl)-aryl bond of the N-phthalimidomethyl derivatives of both ethyl and methyl N-(2,4-dinitrophenyl)carbamate is reported.