911826-36-3

Basic information

• Product Name: 3(2H)-Benzofuranone, 4-fluoro-
• Synonyms: 3(2H)-Benzofuranone, 4-fluoro-;4-Fluorobenzofuran-3(2H)-one
• CAS NO: 911826-36-3
• Molecular Formula: C₈H₅FO₂
• Molecular Weight: 152.13
• Mol File: 911826-36-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3(2H)-Benzofuranone, 4-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-Benzofuranone, 4-fluoro-(911826-36-3)
• EPA Substance Registry System: 3(2H)-Benzofuranone, 4-fluoro-(911826-36-3)

Safety Data

• Hazardous Substances Data: 911826-36-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3(2H)-Benzofuranone, 4-fluorois used as a building block for the synthesis of pharmaceutical compounds. Its unique structure and properties make it a valuable agent in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 3(2H)-Benzofuranone, 4-fluorois utilized as a precursor for the synthesis of agrochemicals, such as pesticides and herbicides. Its reactivity and properties contribute to the development of more effective and environmentally friendly agrochemical products.
Used in Material Science:
3(2H)-Benzofuranone, 4-fluorois employed in material science for the development of new materials with specific properties. Its unique structure and reactivity make it a promising candidate for the synthesis of advanced materials with potential applications in various industries, such as electronics, coatings, and polymers.
Used in Chemical Research and Development:
3(2H)-Benzofuranone, 4-fluorois used as a valuable agent in chemical research and development. Its properties and reactivity make it a promising candidate for further exploration and innovation in the synthesis of new chemical compounds and processes.

Upstream product

• 137654-21-8 2-fluoro-6-methoxybenzoic acid 
• 500912-12-9 2-fluoro-6-methoxybenzoyl chloride 
• 93339-98-1 1-(2-fluoro-6-hydroxyphenyl)ethan-1-one 
• 1038535-33-9 C₈H₆BrFO₂ 
• 178747-79-0 methyl 2-fluoro-6-methoxybenzoate 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 1314713-95-5 (Z)-2-(2,4-difluorobenzylidene)-4-fluorobenzofuran-3(2H)-one 
• 911826-38-5 4-fluoro-2,3-dihydrobenzofuran-3-amine 

Relevant articles and documents

Practical, modular, and general synthesis of 3-coumaranones through gold-catalyzed intermolecular alkyne oxidation strategy

A gold-catalyzed intermolecular alkyne oxidation for the preparation of 3-coumaranones has been developed. Using 8-isopropylquinoline N-oxides as oxidants, the reactions of o-ethynylanisoles afford versatile 3-coumaranones in moderate to good isolated yields. The synthetic utility of this chemistry is also indicated by the synthesis of the natural product sulfuretin.

Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase

We have identified naturally occurring 2-benzylidenebenzofuran-3-ones (aurones) as new templates for non-nucleoside hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors. The aurone target site, identified by site-directed mutagenesis, is located in thumb pocket I of HCV RdRp. The RdRp inhibitory activity of 42 aurones was rationally explored in an enzyme assay. Molecular docking studies were used to determine how aurones bind to HCV RdRp and to predict their range of inhibitory activity. Seven aurone derivatives were found to have potent inhibitory effects on HCV RdRp, with IC50 below 5 μM and excellent selectivity index (inhibition activity versus cellular cytotoxicity). The most active aurone analogue was (Z)-2-((1-butyl-1H-indol-3-yl)methylene)-4,6-dihydroxybenzofuran-3(2H)-one (compound 51), with an IC50 of 2.2 μM. Their potent RdRp inhibitory activity and their low toxicity make these molecules attractive candidates as direct-acting anti-HCV agents.

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The present invention provides novel purinone and related derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formula (III).

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The present invention provides novel purine and imidazopyridine derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulas ( I ) and ( II ).