91192-26-6Relevant academic research and scientific papers
Palladium-Catalyzed Dual Annulation: A Method for the Synthesis of Norneocryptolepine
Yeh, Li-Hsuan,Wang, Hung-Kai,Pallikonda, Gangaram,Ciou, Yu-Lun,Hsieh, Jen-Chieh
supporting information, (2019/03/19)
A novel procedure for the Pd-catalyzed dual annulation reaction to synthesize the norneocryptolepine derivatives involving the concerted construction of two central heterocycles is reported. The further methylation of the norneocryptolepine to afford its alkaloid analog neocryptolepine implies that synthesis of various neocryptolepine derivatives is feasible. The oxidative addition of Pd(0) is indicated as the key step to activate the intramolecular addition of nitrile according to the mechanism study.
JAK2 AND ALK2 INHIBITORS AND METHODS FOR THEIR USE
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, (2014/10/04)
Compounds having activity as inhibitors of ALK2 kinase and/or JAK2 kinase are disclosed. The compounds have the following structure (I): [FORMULA SHOULD BE INSERTED HERE] including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, X, z and A are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
