912353-73-2Relevant academic research and scientific papers
Synthesis and evaluation of novel pyrimidine-based dual EGFR/Her-2 inhibitors
Suzuki, Naoyuki,Shiota, Takeshi,Watanabe, Fumihiko,Haga, Norihiro,Murashi, Takami,Ohara, Takafumi,Matsuo, Kenji,Oomori, Naoki,Yari, Hiroshi,Dohi, Keiji,Inoue, Makiko,Iguchi, Motofumi,Sentou, Jyunko,Wada, Tooru
, p. 1601 - 1606 (2011/05/11)
A structure-activity relationship study of 4-anilinopyrimidines for dual EGFR/Her-2 inhibitor has resulted in the identification of 4-anilino-5-alkenyl or 5-alkynyl-6-methylpyrimidine derivatives that have exhibited effective inhibitory activity against both enzymes. The presence of 5-alkenyl or 5-alkynyl moiety bearing terminal hydrophilic group played important role for inhibition of these enzymes. Selected compounds in the series demonstrated some activity against Her-2 dependent cell line (BT474).
