91271-02-2Relevant academic research and scientific papers
Organophosphorus Compounds, 110. - Specific Fluorescence Labelling of Serine Enzymes
Horner, Leopold,Flemming, Hans-Wolfram
, p. 1 - 21 (2007/10/02)
Compounds of the type R1R2P(O)X are OH-selective and react with the serine hydroxy group in the active site of esterases (α-chymotrypsine, trypsine, butyrylcholinesterase, acetylcholinesterase,and subtilisine) to fo
PHOSPHORORGANISCHE VERBINDUNGEN 108. DIE SYNTHESE FLUORESZIERENDER UND CHEMOSELEKTIVER REAGENTIEN ZUM GEZIELTEN NACHWEIS UND SCHUTZ BIOLOGISCH WICHTIGER FUNKTIONELLER GRUPPEN
Horner, Leopold,Flemming, Hans-Wolfram
, p. 345 - 362 (2007/10/02)
Compounds of type A are fluorescent, if the donator groups, like NMe2, OMe, SMe and PR2, and the acceptor groups, like R'P(O)X, SO2R' and CO2R', are linked to different nuclei of the naphthalin ring system.The chemoselectivity of the electrophilic phosphoryl compounds P(O)X to nucleophiles like ROH, RNHR' and RSH is determined by the nature of the leaving group X responsible for different reaction mechanism.Phosphoryl groups with X = Cl attack predominantly R-NHR'- groups; phosphoryl compounds with X = F and OC6H4NO2(p) are ROH-selective.In this publication compounds of type A are presented, in which fluorescence and chemoselectivity are combined by structure in one molecule.These compounds are important analytic reagents (prove of the functional groups in the active site of enzymes) and as protective groups in the synthesis of natural products like peptides.
