91285-91-5Relevant articles and documents
Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase
Braun, Stephan,Botzki, Alexander,Salmen, Sunnhild,Textor, Christian,Bernhardt, Günther,Dove, Stefan,Buschauer, Armin
experimental part, p. 4419 - 4429 (2011/11/06)
Bacterial hyaluronan lyases (Hyal) degrade hyaluronan, an important component of the extracellular matrix, and are involved in microbial spread. Hyal inhibitors may serve as tools to study the role of the enzyme, its substrates and products in the course of bacterial infections. Moreover, such enzyme inhibitors are potential candidates for antibacterial combination therapy. Based on crystal structures of Streptococcus pneumoniae Hyal in complex with a hexasaccharide substrate and with different inhibitors, 1-acylated benzimidazole-2-thiones and benzoxazole-2-thiones were derived as new leads for the inhibition of Streptococcus agalactiae strain 4755 Hyal. Structure-based optimization led to N-(3-phenylpropionyl)benzoxazole-2-thione, one of the most potent compounds known to date (IC50 values: 24 μM at pH 7.4, 15 μM at pH 5). Among the 27 new derivatives, other N-acylated benzimidazoles and benzoxazoles are just as active at pH 7.4, but not at pH 5. The results support a binding mode characterized by interactions with residues in the catalytic site and with a hydrophobic patch.
On the Use of Five-Membered Heterocycles in Peptide Chemistry
Romani, S.,Moroder, L.,Bovermann, G.,Wuensch, E.
, p. 738 - 742 (2007/10/02)
N-Acyl derivatives of 2-benzoxazolethiol, 2-benzothiazolethiol and 2-benzimidazolethiol are proposed for use both as efficient acylating agents for the synthesis of N-benzyloxycarbonyl and N-fluorenylmethyloxycarbonyl amino acid derivatives and as activated amides for the synthesis of peptides.
