135833-82-8

Usage

Uses

1-(4-Fluorophenyl)-5-methyl-2-phenylhexane-1,4-dione is primarily used as a stimulant drug for its psychoactive effects, which include increased energy, euphoria, and heightened sensory perception. However, due to its high potential for abuse and dependence, it is often regulated as a controlled substance in many countries. The specific applications and industries where it is used are not mentioned in the provided materials.

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 912998-81-3 methyl 4-methyl-3-oxo-2-(phenylmethylene)pentanoate 
• 912998-82-4 (+/-)methyl 2-(2-(4-fluorophenyl)-2-oxo-1-phenylethyl)-4-methyl-3-oxopentanoate 
• 563-80-4 3-methyl-butan-2-one 
• 347-84-2 1-(4-fluorophenyl)-2-phenylethanone 
• 19967-55-6 1-bromo-3-methyl-2-butanone 
• 100-52-7 benzaldehyde 
• 42558-54-3 Methyl 4-methyl-3-oxopentanoate 

Downstream Products

• 135833-83-9 1-(3,3-diethoxypropyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-1H-pyrrole 
• 1262052-11-8 1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-2-(4-fluorophenyl)-5-isopropyl-3-phenyl-1H-pyrrole 
• 1026685-96-0 tert-butyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate 
• 135834-14-9 (4R,6R)-6-{2-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-ethyl}-4-hydroxy-tetrahydro-pyran-2-one 
• 135834-02-5 3-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-propionaldehyde 

Relevant academic research and scientific papers

Copper-Catalyzed Regioselective Monodefluoroborylation of Polyfluoroalkenes en Route to Diverse Fluoroalkenes

Monodefluoroborylation of polyfluoroalkenes has been achieved in a regioselective manner under mild conditions via copper catalysis. The method has shown an extremely broad scope of substrates, including (difluorovinyl)arenes, tetrafluoroethylene (TFE), (

METHOD FOR THE PREPARATION OF ATORVASTATIN AND INTERMEDIATES USED THEREIN

The present invention relates to a novel method for preparing atorvastatin. According to the present invention, provided are a novel intermediate of the preparation of atorvastatin and a method of preparing large amounts of atorvastatin in a safe manner using the intermediate.

METHOD FOR THE PREPARATION OF ATORVASTATIN AND INTERMEDIATES USED THEREIN

The present invention relates to a novel method for preparing atorvastatin. According to the present invention, provided are a novel intermediate of the preparation of atorvastatin and a method of preparing large amounts of atorvastatin in a safe manner using the intermediate.

PYRROLE COMPOUNDS AND USES THEREOF

Pyrrole compounds, compositions and methods are provided for the treatment, prevention, or amelioration of neurodegenerative diseases, cardiovascular diseases, proliferative diseases and visual disorders. In particular, pyrrole compounds, compositions and methods for the treatment of stroke are disclosed herein.

Inhibitors of Cholesterol Biosynthesis. 3. Tetrahydro-4-hydroxy-6--2H-pyran-2-one Inhibitors of HMG-CoA Reductase. 2. Effects of Introducing Substituents at Positions Three and Four of the Pyrrole Nucleus

A series of trans-tetrahydro-4-hydroxy-6--2H-pyran-2 ones and their dihydroxy acids were prepared and tested for their ability to inhibit the enzyme HMG-CoA reductase in vitro.Inhibitory potency was found to increase subtantially when substituents were introduced into positions three and four of the pyrrole ring.A systematic exploration of structure-activity relationships at these two positions led to the identification of a compound ((+)-33, (+)-(4R)-trans-2-(4-fluorophenyl)-5-(1-methylethyl)-N,3-diphenyl-1- -1H-pyrrole-4-carboxamide) with five times the inhibitory potency of the fungal metabolite compactin.