913558-33-5Relevant academic research and scientific papers
NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2, 3-DIOXYGENASE (IDO) INHIBITORS
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Page/Page column 143; 144; 145, (2020/06/19)
Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
Pyrazole acids as niacin receptor agonists for the treatment of dyslipidemia
Schmidt, Darby,Smenton, Abigail,Raghavan, Subharekha,Carballo-Jane, Ester,Lubell, Silvi,Ciecko, Tanya,Holt, Tom G.,Wolff, Michael,Taggart, Andrew,Wilsie, Larissa,Krsmanovic, Mihajlo,Ren, Ning,Blom, Daniel,Cheng, Kang,McCann, Peggy E.,Gerard Waters,Tata, James,Colletti, Steven
scheme or table, p. 4768 - 4772 (2010/04/28)
Niacin is an effective drug for raising HDL cholesterol and reducing coronary risks, but patients show low compliance with treatment due to severe facial flushing upon taking the drug. A series of bicyclic pyrazole carboxylic acids were synthesized and tested for their ability to activate the niacin receptor. One analog, 23, showed improved potency and lacked flushing at doses that effectively altered the lipid profile of rats.
NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
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Page/Page column 30; 31, (2008/06/13)
The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating dyslipidemias. Pharmaceutical compositions and methods of use are also included.
