913617-04-6

Basic information

• Product Name: (11BR)-2,6-BIS(DIPHENYLPHOSPHINO)-N,N-DIMETHYLDINAPHTHO(2,1-D:1',2'-F)-1,3,2-DIOXAPHOSPHEPIN-4-AMINE, KANATA PURITY
• Synonyms: (11BR)-2,6-BIS(DIPHENYLPHOSPHINO)-N,N-DIMETHYLDINAPHTHO(2,1-D:1',2'-F)-1,3,2-DIOXAPHOSPHEPIN-4-AMINE, KANATA PURITY;(11bR)-2,6-Bis(diphenylphosphino)-N,N-dimethyldinaphtho[2,1-d:1μ,2μ-f]-1,3,2-dioxaphosphepin-4-amine
• CAS NO: 913617-04-6
• Molecular Formula: C46H36NO2P3
• Molecular Weight: 727.704823
• Product Categories: DSM MonoPhos Phosphoramidites;Chiral Catalysts, Ligands, and Reagents;Privileged Ligands and Complexes
• Mol File: 913617-04-6.mol

Chemical Properties

• Melting Point: 245-249 °C
• Appearance: /
• Storage Temp.: 2-8°C
• PKA: 0.85±0.20(Predicted)
• CAS DataBase Reference: (11BR)-2,6-BIS(DIPHENYLPHOSPHINO)-N,N-DIMETHYLDINAPHTHO(2,1-D:1',2'-F)-1,3,2-DIOXAPHOSPHEPIN-4-AMINE, KANATA PURITY(CAS DataBase Reference)
• NIST Chemistry Reference: (11BR)-2,6-BIS(DIPHENYLPHOSPHINO)-N,N-DIMETHYLDINAPHTHO(2,1-D:1',2'-F)-1,3,2-DIOXAPHOSPHEPIN-4-AMINE, KANATA PURITY(913617-04-6)
• EPA Substance Registry System: (11BR)-2,6-BIS(DIPHENYLPHOSPHINO)-N,N-DIMETHYLDINAPHTHO(2,1-D:1',2'-F)-1,3,2-DIOXAPHOSPHEPIN-4-AMINE, KANATA PURITY(913617-04-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 913617-04-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(11BR)-2,6-BIS(DIPHENYLPHOSPHINO)-N,N-DIMETHYLDINAPHTHO(2,1-D:1',2'-F)-1,3,2-DIOXAPHOSPHEPIN-4-AMINE, KANATA PURITY is used as a chiral ligand in the pharmaceutical industry for the stereoselective preparation of aminoesters. This application is crucial for the synthesis of enantiomerically pure pharmaceutical compounds, which can have different biological activities and reduce the risk of side effects.
Used in Chemical Synthesis:
In the field of chemical synthesis, (11BR)-2,6-BIS(DIPHENYLPHOSPHINO)-N,N-DIMETHYLDINAPHTHO(2,1-D:1',2'-F)-1,3,2-DIOXAPHOSPHEPIN-4-AMINE, KANATA PURITY serves as a ligand for the rhodium-catalyzed enantioselective hydrogenation of dehydroaminoesters. This process is essential for the production of chiral amines, which are key building blocks in the synthesis of various biologically active molecules and pharmaceuticals.
Used in Asymmetric Catalysis:
(11BR)-2,6-BIS(DIPHENYLPHOSPHINO)-N,N-DIMETHYLDINAPHTHO(2,1-D:1',2'-F)-1,3,2-DIOXAPHOSPHEPIN-4-AMINE, KANATA PURITY is also utilized in asymmetric catalysis for the Rh-catalyzed asymmetric hydrogenation of N-(α-arylvinyl) acetamides. This reaction is significant for the preparation of chiral amide compounds, which are important intermediates in the synthesis of complex organic molecules and pharmaceutical agents.
Overall, (11BR)-2,6-BIS(DIPHENYLPHOSPHINO)-N,N-DIMETHYLDINAPHTHO(2,1-D:1',2'-F)-1,3,2-DIOXAPHOSPHEPIN-4-AMINE, KANATA PURITY is a versatile ligand with applications in various industries, particularly in the synthesis of enantiomerically pure compounds for pharmaceutical and chemical applications. Its unique structure and properties make it a valuable tool in the development of new and improved synthetic methods.

Upstream product

• 1608-26-0 Hexamethylphosphorous triamide 
• 18531-94-7 (R)-1,1'-Bi-2-naphthol 

Relevant articles and documents

Synthesis of triphosphorous bidentate phosphine-phosphoramidite ligands: Application in the highly enantioselective hydrogenation of ortho-substituted aryl enamides

New couple: A novel combination of phosphine and phosphoramidite groups is applied to the preparation of pseudo-C2-symmetric triphosphorous bidentate phosphine-phosphoramidite ligands 1. Unprecedented enantioselectivities toward ortho-substituted aryl enamides and a 1-naphthylenamide in Rh-catalyzed hydrogenation reactions are obtained. (Chemical Equation Presented).