913655-91-1Relevant academic research and scientific papers
Catalytic addition of homoenolates to imines - The homo-Mannich reaction
Abbas, Muhammad,Neuhaus, Christiane,Krebs, Birte,Westermann, Bernhard
, p. 473 - 476 (2005)
For the first time, homo-Mannich reactions with unmasked homoenolates have been achieved by adding homoenolate precursor 1 and imines 5. The key to this reaction is the right choice of the Lewis acids - Cu(OTf)2 proved to be most suitable for p
Efficient synthesis of 1-azadienes derived from α-aminoesters. Regioselective preparation of α-dehydroamino acids, vinylglycines, and α-amino acids
Palacios, Francisco,Vicario, Javier,Aparicio, Domitila
, p. 7690 - 7696 (2007/10/03)
(Chemical Equation Presented) An efficient synthesis of 1-azadienes derived from α-aminoesters is achieved through an aza-Wittig reaction of phosphazenes with β,γ-unsaturated α-ketoesters. Regioselective 1,2-reduction of these functionalized 1-azadienes affords vinylglycine derivatives, while conjugative 1,4-reduction gives α-dehydroamino acid compounds. Reduction of both the carbon-carbon and the imine-carbon-nitrogen double bonds leads to the formation of α-amino acid derivatives.
