91374-55-9Relevant articles and documents
C-ALKYLATION OF PHENOLS WITH METHYL VINYL KETONE IN THE PRESENCE OF BASES
Titova, T. F.,Krysin, A. P.,Shakirov, M. M.,Mamatyuk, V. I.
, p. 294 - 301 (2007/10/02)
The C-alkylation of phenols with methyl vinyl ketone in alcohols in the presence of alkali-metal alcoholates at -60 to +40 deg C was investigated by the PMR method.At -30 to 0 deg C methyl vinyl ketone reacts with primary alcohols with the formation of β-alkoxy-2-butanones, the subsequent reaction of which with 2,6-di-tert-butylphenol at 20-40 deg C by a mechanism of nucleophilic substitution leads to the formation of 4-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-butanone.The composition of the products from the reaction of 2,6-di-tert-butylphenol with methyl vinyl ketone and β-methoxy-2-butanone was studied.