5082-72-4Relevant academic research and scientific papers
Manganese-catalyzed dehydrogenative Csp3-Csp2coupling of imidazo[1,2-a]pyridines with methyl ketones
Yao, Hua,Zhong, Xiaoyang,Wang, Bingqing,Lin, Sen,Liu, Lichi,Yan, Zhaohua
, p. 3479 - 3483 (2021)
A Mn(ii)-catalyzed efficient C-H alkylation of imidazoheterocycles with methyl ketones has been developedviadehydrogenative C(sp3)-C(sp2) coupling which can serve as a novel approach toward hydrocarboxylated imidazolopyridines. The merit of this strategy is illustrated by excellent functional group tolerance and the use of cheap and readily available starting materials.
Synthetic method of high-purity raspberry ketone
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Paragraph 0033-0042, (2021/11/21)
The invention belongs to the technical field of perfumes and fine chemical engineering. The invention specifically relates to a synthesis method of high-purity raspberry ketone. To the synthesis method, 2 and 6 - di-tert-butyl phenol are used as raw materials, and the butanone or a-hydroxybutanone is subjected to alkylation reaction under the catalysis condition of the acid catalyst 4 - to generate 2 and 6 - b di-tert-butyl -4 -hydroxybenzyl acetone. To the invention, 2, 6 -position occupying-protected phenol 2 and 6 - di-tert-butyl phenol are used as raw materials, and the butanone or 4 -hydroxybutanone alkylation reaction can 100% position in the para position, and the obtained 2 and 6 - di-tert-butyl -4 -hydroxybenzyl acetone. Yield. A tert-butyl process is performed, so that high-yield and high-purity raspberry ketone is obtained. The method is simple in process, short in reaction time, high in product purity, recyclable in reaction byproducts, recyclable in catalyst, low in cost and suitable for industrial production.
Synthesis and characterization of novel phenolic derivatives with the glycerol ketal group as an efficient antioxidant for gasoline stabilization
Namazifar, Zeinab,Saadati, Fariba,Miranbeigi, Ali Akbar
, p. 10038 - 10044 (2019/07/04)
The development of antioxidants with phenol, hydroxyl, and ketal functional groups provides a creative approach to preventing the degradation of stored petroleum-derived products such as gasoline. The present study proposes a simple and efficient protocol
Radical Chain Addition of Aryloxyl Radicals to Electron-deficient Alkeanes
Baik, Woonphil,Min, Byeong Cheol,Lee, Ki Chang,Jun, Young Moo,Kim, Byeong Hyo
, p. 366 - 367 (2007/10/03)
Michael addition of aryloxyl radicals to electron-deficient alkenes in the presence of Ag+ is described.
AMBERLYST-15 CATALYZED ADDITION OF PHENOLS TO α,β-UNSATURATED KETONES
Bunce, Richard A.,Reeves, Henry D.
, p. 1109 - 1118 (2007/10/02)
Amberlyst-15 has been used to catalyze regioselective additions of phenols to α,β-unsaturated ketones in yields of 20-90percent.The reaction is superior to the analogous reaction employing concentrated sulfuric acid in affording greater yields and purer products with a minimum of laboratory operations.
C-ALKYLATION OF PHENOLS WITH METHYL VINYL KETONE IN THE PRESENCE OF BASES
Titova, T. F.,Krysin, A. P.,Shakirov, M. M.,Mamatyuk, V. I.
, p. 294 - 301 (2007/10/02)
The C-alkylation of phenols with methyl vinyl ketone in alcohols in the presence of alkali-metal alcoholates at -60 to +40 deg C was investigated by the PMR method.At -30 to 0 deg C methyl vinyl ketone reacts with primary alcohols with the formation of β-alkoxy-2-butanones, the subsequent reaction of which with 2,6-di-tert-butylphenol at 20-40 deg C by a mechanism of nucleophilic substitution leads to the formation of 4-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-butanone.The composition of the products from the reaction of 2,6-di-tert-butylphenol with methyl vinyl ketone and β-methoxy-2-butanone was studied.
