913827-72-2Relevant academic research and scientific papers
Preparation of disubstituted phenyl propargyl alcohols, their use in oxathiolene oxide synthesis, and evaluation of the oxathiolene oxide products as anticarcinogenic enzyme inducers
Ying, Maben,Smentek, Matthew G.,Ma, Rong,Day, Cynthia S.,Torti, Suzy V.,Welker, Mark E.
experimental part, p. 242 - 251 (2010/04/23)
A number of alkynols have been prepared by Sonogoshira coupling of propargyl alcohol to disubstituted aromatic halides. Chelation controlled addition of organometallic nucleophiles to these alkynols was then affected followed by the addition of sulfur dio
Synthesis of the parent and substituted tetracyclic ABCD ring cores of camptothecins via 1-(3-aryl-2-propynyl)-1,6-dihydro-6-oxo-2- pyridinecarbonitriles
Dai, Weixiang,Petersen, Jeffrey L.,Wang, Kung K.
, p. 4665 - 4667 (2007/10/03)
A new synthetic pathway to the parent and substituted ABCD ring cores of the camptothecin family of alkaloids was developed. The N-alkylation of 1,6-dihydro-6-oxo-2-pyridinecarbonitrile (2) with 3-bromo-1-phenylpropyne provided 3a using Curran's protocol.
