25245-33-4

Usage

Uses

1-Iodo-2,3-dimethoxybenzene is used in the preparation of fused heterocyclic amido compounds as a potential anti hepatitis C virus agents.

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 1729-32-4 5-iodomethyl-dihydro-furan-2-one 
• 92669-91-5 1-trimethylsilyl-2,3-dimethoxybenzene 
• 101252-15-7 2,3-dichloro-5,6-dimethoxy-aniline 
• 116668-84-9 3-nitroveratrole 
• 15969-08-1 6-methoxy-2-nitrophenol 
• 1521-39-7 2,3-dimethoxybenzamide 

Downstream Products

• 145059-62-7 3-(cyclohex-2-en-1-yl)-1,2-dimethoxybenzene 
• 171087-98-2 [2-(2,3-dimethoxyphenyl)ethynyl]trimethylsilane 
• 19337-60-1 3-iodo-1,2-benzenediol 
• 1293343-71-1 4-[2-(2,3-dimethoxyphenylsulfanyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester 
• 1293342-99-0 1-[2-(2,3-dimethoxyphenylsulfanyl)phenyl]piperazine hydrochloride 
• 1293343-36-8 1-(2-bromophenylsulfanyl)-2,3-dimethoxybenzene 
• 1307741-29-2 N-butyl-2,3-dimethoxyaniline 
• 1307741-72-5 N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodo-5-methoxybenzamide 
• 1307741-70-3 N-butyl-N-[7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzo[d][1,3]dioxol-4-yl]-2-iodobenzamide 
• 1307741-62-3 2-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-5-butyl-3,4,8-trimethoxyphenanthridin-6(5H)-one 
• 1307741-58-7 2-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-5-butyl-3,4-dimethoxyphenanthridin-6(5H)-one 
• 1307741-54-3 C₃₀H₃₀F₆INO₅ 
• 1307741-50-9 N-butyl-N-[4-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-2,3-dimethoxyphenyl]-2-iodobenzamide 
• 1307741-47-4 C₂₃H₂₄F₆INO₅ 

Relevant academic research and scientific papers

Aryl iodides from aryllithiums using an iodolactone as an iodine electrophile

The paper describes the use of iodolactone 2 as an iodine electrophile for transforming aryllithiums into aryl iodides.

THIOXANTHONE DERIVATIVES, COMPOSITION COMPRISING THE SAME AND PATTERN FORMING METHOD COMPRISING SAID COMPOSITION

Latent photoinitiator compounds are described, as well as compositions containing such compounds and their uses in photoinitated methods for producing photoresist structures.

BIARYL DERIVATIVE AS GPR120 AGONIST

The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.

Potassium-alkyl magnesiates: Synthesis, structures and Mg-H exchange applications of aromatic and heterocyclic substrates

Using structurally well-defined dipotassium-tetra(alkyl)magnesiates, a new straightforward methodology to promote regioselective Mg-H exchange reactions of a wide range of aromatic and heteroaromatic substrates is disclosed. Contacted ion pair intermediates are likely to be involved, with K being the key to facilitate the magnesiation processes. This journal is

THERAPEUTIC AGENT FOR HEPATITIS C

This invention provides a therapeutic agent for hepatitis C comprising, as an active ingredient, a compound having anti-HCV activity useful in treatment of hepatitis C. The therapeutic agent for hepatitis C comprises, as an active ingredient, a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

Environmental friendly method for the iodination of moderately active arenes

An effective and environmental friendly method for the iodination of various moderately active methoxy arenes, phenols and anilines using hydrogen peroxide and acidified sodium periodate in aqueous ethanol medium is reported. The extent of iodination is e

Fused heterocyclic amido compounds as anti-hepatitis C virus agents

We identified a fused heteroaromatic amido structure based on the phenanthridine skeleton as a superior scaffold for candidate drugs with potent anti-HCV activity. Among the compounds synthesized, a phenanthridine analogue with a 1,3-dioxolyl group (24) possessed the most potent anti-HCV activity (EC50 value: 50 nM), with acceptable cytotoxicity. The structural development and structure-activity relationships of these compounds are described.

Deprotonative metalation of substituted aromatics using mixed lithium-cobalt combinations

The deprotonation of anisole was attempted using different homo- and heteroleptic TMP/Bu mixed lithium-cobalt combinations. Using iodine to intercept the metalated anisole, an optimization of the reaction conditions showed that in THF at room temperature 2 equiv of base were required to suppress the formation of the corresponding 2,2′-dimer. The origin of the dimer was not identified, but its formation was favored with allyl bromide as electrophile. The metalated anisole was efficiently trapped using iodine, anisaldehyde, and chlorodiphenylphosphine, and moderately employing benzophenone, and benzoyl chloride. 1,2-, 1,3-, and 1,4-dimethoxybenzene were similarly converted regioselectively to the corresponding iodides. It was observed that 2-methoxy- and 2,6-dimethoxypyridine were more prone to dimerization than the corresponding benzenes when treated similarly. Involving ethyl benzoate in the metalation-iodination sequence showed that the method was not suitable to functionalize substrates bearing reactive functions.

Deprotonative metalation of functionalized aromatics using mixed lithium-cadmium, lithium-indium, and lithium-zinc species

In situ mixtures of CdCl2TMEDA (0.5 equiv; TMEDA = N,N,N',N'-tetramethylethylenediamine) or InCl3 (0.33 equiv) with [Li(tmp)] (tmp = 2,2,6,6-tetramethylpiperidino; 1.5 or 1.3 equiv, respectively) were compared with the previously described mixture of ZnCl2-TMEDA (0.5 equiv) and [Li(tmp)] (1.5 equiv) for their ability to deprotonate anisole, benzothiazole, and pyrimidine. [(tmp)3CdLi] proved to be the best base when used in tetrahydrofuran at room temperature, as demonstrated by subsequent trapping with iodine. The Cd-Li base then proved suitable for the metalation of a large range of aromatics including benzenes bearing reactive functional groups (CONEt2, CO2Me, CN, COPh) or heavy halogens (Br, I), and heterocycles (from the furan, thiophene, pyrrole, oxazole, thiazole, pyridine, and diazine series). Fivemembered heterocycles benefiting from doubly activated positions were similarly dideprotonated at room temperature. The aromatic lithium cadmates thus obtained were involved in palladium-catalyzed cross-coupling reactions or simply quenched with acid chlorides.

Columnar mesophases from half-discoid platinum cyclometalated metallomesogens

A series of liquid crystals have been synthesized and studied based upon mononuclear ortho-platinated rod-like heteroaromatic and 1,3-diketonate ligands. The liquid crystalline properties of these molecules were investigated using polarized light optical